Results 51 to 60 of about 13,598,018 (237)
Animal Research and One Health, EarlyView.The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang +4 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2012 Background To understand the role of proteases involved in human thyroid cancer progression and tissue invasion, thyrocytes from other species could potentially be used provided their characteristics are similar.
Fröhlich Eleonore +2 more
doaj +1 more source
Purification of an Aminopeptidase Preferentially Releasing N-terminal Alanine from Cucumber Leaves and Its Identification as a Plant Aminopeptidase N [PDF]
Bioscience, Biotechnology, and Biochemistry, 2001 In this study, a highly active foliar aminopeptidase preferentially releasing N-terminal alanine from artificial substrates was purified and characterized from cucumber (Cucumis sativus L. suyo). The enzyme had a molecular mass of 200 kDa consisting of two subunits of 95 kDa. It was a metalloprotease the pH optimum of which was 8 to 9. It cleaved Ala-,
YAMAUCHI, Yasuo +2 more
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iMetaMed, EarlyView.This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu +7 more
wiley +1 more source
Local renin angiotensin system and sperm DNA fragmentation
Asian Journal of Andrology, 2022 The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto +6 more
doaj +1 more source
CD13/aminopeptidase N and murine cytomegalovirus infection [PDF]
Virology, 2005 CD13/aminopeptidase N is a membrane-bound metalloproteinase implicated in human cytomegalovirus (HCMV) infection and pathogenesis. Anti-CD13 antibodies can neutralize HCMV infectivity, and HCMV viremia after bone marrow transplantation induces anti-CD13 autoantibodies which correlate with development of chronic graft vs. host disease.
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Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Surface molds contribute to flavor development in dry‐cured fermented sausages through their effects on proteolysis, amino acid catabolism, and volatile compound formation. This study evaluated the influence of Aspergillus oryzae, Penicillium camemberti, Penicillium roqueforti and Penicillium nalgiovense on the evolution of free ...
José María Martín‐Miguélez +4 more
wiley +1 more source
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
PLoS ONE, 2008 BackgroundEndoplasmic reticulum aminopeptidase 1 (ERAP1) trims N-terminally extended antigenic peptide precursors down to mature antigenic peptides for presentation by major histocompatibility complex (MHC) class I molecules.
Irini Evnouchidou +7 more
doaj +1 more source
Variable O-glycosylation of CD13 (aminopeptidase N)
Journal of Biological Chemistry, 1991 The monoclonal antibody AG6 was raised against HUVE cells and was confirmed as recognizing CD13 (aminopeptidase N) by its reactivity with the CD13 cDNA transfectant pipz "4". However, in sequential immunoprecipitation studies with another anti-CD13 monoclonal, WM15, neither was able to completely remove the molecules recognized by the other.
P J, O'Connell, V, Gerkis, A J, d'Apice
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Effects of Straw Incorporation and Tillage Depth on Soil Quality in Mollisol Profiles
Land Degradation &Development, EarlyView.ABSTRACT Although improvements in soil quality under straw incorporation have been well documented, responses across soil profiles under different tillage depths remain unclear. To address this issue, a field experiment was established in 2011 in Mollisols with conventional tillage (20 cm depth) without straw (CT) and with straw (SCT), no tillage with ...
Yu Xu +6 more
wiley +1 more source