Results 71 to 80 of about 27,424 (235)

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer

BMC Cancer, 2008
Background Radiotherapy can be used to treat all stages of cervical cancer. For improving local control via radiotherapy, it is important to use additional antitumor agents.
Nawa Akihiro, Terauchi Mikio, Kajiyama Hiroaki, Shibata Kiyosumi, Tsukamoto Hirohisa, Kikkawa Fumitaka   +5 more
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, EarlyView.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Crystal structure of X‐prolyl aminopeptidase fromCaenorhabditis elegans: A cytosolic enzyme with a di‐nuclear active site

FEBS Open Bio, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X‐prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N‐terminus of peptides possessing a penultimate N‐terminal proline residue.
Shalini Iyer, Penelope J. La-Borde, Karl A.P. Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya   +6 more
doaj   +1 more source

Degradable versus inert microplastics: Effects on soil organic carbon persistence via microbial drivers in an agroecosystem

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Microplastics (MPs) are widespread in terrestrial ecosystems, raising global concerns that they may disrupt soil organic carbon (SOC) cycling and undermine agroecosystem contributions to climate mitigation.
Meng‐Ying Li, Wei Wang, Yue Ma, Jia‐Yao Yang, Shu‐Tong Liu, Xiao‐Bin Xiong, Tingting Zhao, Yuanze Sun, Saddam Saqib, Muhammd Ashraf, Matthias C. Rillig, You‐Cai Xiong   +11 more
wiley   +1 more source

Comparative Analysis of CrylAc Toxin Oligomerization and Pore Formation Between Bt-Susceptible and Bt-Resistant Helicoverpa armigera Larvae

Journal of Integrative Agriculture, 2012
With the long-term use of Bacillus thuringiensis (Bt) insecticide and expansion of Cry1A-expressing transgenic plants, some insect pests have developed resistance to Bt in open fields, greenhouses, and in the laboratory.
Yi-ping LI, Jun-xiang WU, Chen-xi LIU, Xiang-qun YUAN, Kong-ming WU, Ge-mei LIANG, Yu-yuan GUO   +6 more
doaj   +1 more source

HNF1α activates the aminopeptidase N promoter in intestinal (Caco-2) cells

, 1994
The importance of HNF1 binding proteins for intestinal aminopeptidase N expression was investigated using the Caco-2 cell-line. Aminopeptidase N promoter activity in Caco-2 cells depends on the HNF1 element (positions −85 to −58) and co-transfection with
Olsen, Jørgen, Jørgen Olsen, Troelsen, Jesper, Laustsen, Liselotte, Liselotte Laustsen, Jesper Troelsen   +5 more
core   +1 more source

Bio‐organic fertilizer alleviated soil microbial C limitations, aggravated P limitations and increased microbial C use efficiency in a degraded desert steppe

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Bio‐organic fertilizer (BOF), which integrates organic carbon sources, beneficial microorganisms and essential nutrients, represents a distinctive approach to grassland restoration that differs fundamentally from conventional fertilization practices.
Yao Zhou, Wen Li, Jing Ma, Jinzhen Li, Haixin Jiang, Guohui Wang, Yan Shen, Hongbin Ma   +7 more
wiley   +1 more source

Knockout of aminopeptidase N3 confers resistance to low concentrations of Bacillus thuringiensis Cry4Ba protoxin in Aedes aegypti

Parasites & Vectors
Background Bacillus thuringiensis is widely employed for biological control. It can effectively suppress populations of various mosquito species, including Aedes aegypti.
Xiaozhen Yang, Wanting Huang, Jiajia Wei, Xiaoxuan Xu, Jackson Champer, Lingling Zhang, Junxiang Wang   +6 more
doaj   +1 more source

Biliary aminopeptidase-N and the cholesterol crystallisation defect in cholelithiasis

, 1995
Several biliary proteins have cholesterol crystallisation promoting activity. One of these glycoproteins is aminopeptidase-N, a canalicular ectoenzyme. This study attempted to localise aminopeptidase-N along the biliary tree, to assess its concentration ...
Mingrone, Geltrude
core  

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source