Results 61 to 70 of about 27,424 (235)

Assignment of the human aminopeptidase N (peptidase E) gene to chromosome 15q13-qter

, 1988
The gene for aminopeptidase N (EC 3.4.11.2) has been located on the human chromosome 15q13-qter using HindIII-cleaved DNA from a panel of hybrids between rodent and human cells.
Olsen, Jørgen, Jørgen Olsen, Sjöström, Hans, Bolund, L, Hans Sjöström, Kruse, T A, Ove Norén, Hans Hilger Ropers, Torben A. Kruse, Grzeschik, Karl-Heinz, Kruse, Torben A., Ropers, Hans Hilger, Bolund, Lars, Grzeschik, K H, Ropers, H H, Karl-Heinz Grzeschik, Norén, O, Lars Bolund, Norén, Ove, Sjöström, H   +19 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Characterization of the Lactococcus lactis pepN gene encoding an aminopeptidase homologous to mammalian aminopeptidase N [PDF]

FEBS Letters, 1992
The nucleotide sequence of the pepN gene from Lactococcus lactis encoding a zinc‐metallo aminopeptidase has been determined. The open reading frame of 2,538 base pairs encodes a protein with a calculated M r of 95,368, which agrees with the apparent M r of 95,000 of the gene product which was identified by polyclonal antibodies raised against the ...
TAN, PST, VANALENBOERRIGTER, IJ, POOLMAN, B, SIEZEN, RJ, DEVOS, WM, KONINGS, WN   +5 more
openaire   +3 more sources

Bt agave: why it is time to explore a new biotechnological frontier

Pest Management Science, EarlyView.
Drylands cover 41% of Earth, requiring sustainable crops. Agave, drought‐ and heat‐adapted, offers high‐value products with low water needs. Pests limit yield, yet Bacillus thuringiensis (Bt) Cry proteins, successful in other plants, remain unexploited in Agave.
Aline Vitória Corim Marim, Marcelo Falsarella Carazzolle, Gonçalo Amarante Guimarães Pereira, Carolina Rossi De Oliveira   +3 more
wiley   +1 more source

DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

eLife, 2016
The aminopeptidase DPP9 removes dipeptides from N-termini of substrates having a proline or alanine in second position. Although linked to several pathways including cell survival and metabolism, the molecular mechanisms underlying these outcomes are ...
Daniela Justa-Schuch, Maria Silva-Garcia, Esther Pilla, Michael Engelke, Markus Kilisch, Christof Lenz, Ulrike Möller, Fumihiko Nakamura, Henning Urlaub, Ruth Geiss-Friedlander   +9 more
doaj   +1 more source

Purification and Characterization of Aminopeptidase B from Oysters (Alectryonella plicatula )(褶牡蛎氨肽酶B的分离纯化和性质研究) [PDF]

Shipin kexue jishu xuebao, 2017
Aminopeptidase is a kind of exopeptidases that specifically cleaves amino acids from the N-terminal of proteins, and thus has wild applications in food industry.
TANG Yi(唐逸), YAN Longjie(颜龙杰), ZHONG Chan(钟婵), ZHANG Lingjing(张凌晶), WENG Ling(翁凌), CAO Minji(曹敏杰)   +5 more
doaj   +1 more source

Aminopeptidase N

, 2013
The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing
openaire   +1 more source

Characterization of four midgut aminopeptidase N isozymes from Ostrinia furnacalis strains with different susceptibilities to Bacillus thuringiensis

, 2014
The full-length cDNA of four Ofapn aminopeptidases were cloned and sequenced from susceptible and resistant Ostrinia furnacalis strains. Four sequences were identified as APN because they shared the common structural features with APN from Lepidoptera ...
Wang, Z, Gatehouse, AMR, Edwards, MG, Xu, Lina, Ferry, N, Zhang, J, He, K   +6 more
core   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization

Cell Reports
Summary: Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the ...
Leire Bejarano, Alberto Hernández-Barranco, Vincent Roh, Rui Santalla Méndez, Eleni Lamprou, Catia F. Costa, Michelle Ballabio, Monika E. Hegi, Nadine Fournier, Johanna A. Joyce   +9 more
doaj   +1 more source