Brain PDGFRβ<sup>+</sup> Cells Exhibit Diverse Reactive Phenotypes After Stroke Without Requiring KLF4. [PDF]
GliaBrain PDGFRβ+ cells become reactive and adopt diverse phenotypes after stroke. Reactive PDGFRβ+ cells exhibit predictable spatial distribution relative to glial scar. KLF4 is not required to mediate the reactivity of brain PDGFRβ+ cells after stroke.
Manrique-Castano D, ElAli A.
europepmc +2 more sources
Clinical and Translational Medicine, 2020 Rationale CD13 is a new marker for liver cancer stem cells (CSCs) that contributes to sorafenib resistance in hepatocellular carcinoma (HCC). However, the underlying mechanism of CD13 in HCC sorafenib resistance remains enigmatic.
Jia Fan, Wei Guo, Xin-Rong Yang
exaly +2 more sources
CD13 identifies S100A4+ immunosuppressive monocytes and predicts temozolomide benefit in glioblastoma [PDF]
Biology DirectBackground Glioblastoma (GBM) is an immunologically “cold” tumor in which S100A4-driven immunosuppressive myeloid cells promote progression and resistance.
Dong Yu, Ruiyao Hu, Qing Zhu, Xiao Wang
doaj +2 more sources
CD13 Inhibition Enhances Cytotoxic Effect of Chemotherapy Agents
Frontiers in Pharmacology, 2018 Multidrug resistance (MDR) of hepatocellular carcinoma is a serious problem. Although CD13 is a biomarker in human liver cancer stem cells, the relationship between CD13 and MDR remains uncertain. This study uses liver cancer cell model to understand the
Zhiqin Gao, Chunyan Fang, Mei-Hua Qu
exaly +3 more sources
Identification of a Novel <i>KRAS::ETNK1</i> Fusion Transcript in a Myelodysplastic/Myeloproliferative Overlap Syndrome With Eosinophilia: A Case Report. [PDF]
EJHaemABSTRACT This work describes, to our knowledge, the first reported case of a patient with an MDS/MPN overlap syndrome harboring a novel KRAS::ETNK1 fusion transcript. The disease initially presented with eosinophilia, megakaryocyte expansion, mast cell infiltration, and a background of typical MDS/MPN‐associated mutations (ASXL1, TET2, EZH2, BCOR, and ...
Caledec M +17 more
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CD13 is a bona-fide marker of bovine pre-adipocytes with potential in cultivated fat applications [PDF]
npj Science of FoodDespite its significant potential, cultivated fat manufacture remains a relatively inefficient process, as it primarily uses source preparations of animal-derived mesenchymal stem/stromal cells (MSC) that are poorly defined and highly heterogenous in ...
Seungmee Lee +4 more
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CD13 activation assembles phosphoinositide (PI) signaling complexes to regulate the actin cytoskeleton [PDF]
Scientific ReportsActivation of transmembrane CD13 enables diverse cellular processes such as cell–cell and cell–matrix adhesion, endocytosis, and recycling of cell surface proteins by assembling and tethering protein complexes at the plasma membrane.
Emily Meredith +8 more
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Anti-Tumor Targeted Drug Delivery Systems Mediated by Aminopeptidase N/CD13
Acta Pharmaceutica Sinica B, 2011 Aminopeptidase N (APN)/CD13 is a transmembrane glycoprotein, which is overexpressed on tumor neovascular endothelial cells and most tumor cells, where it plays an important role in tumor angiogenesis.
Xun Wang, Bin Wang, Qiang Zhang
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Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA [PDF]
Iranian Journal of Immunology, 2020 Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV
Khadijeh Ramezani Ali Akbari +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Aminopeptidase N, or CD13, is a cell membrane ectopeptidase highly expressed in myeloid cells. Through its enzymatic activity, CD13 regulates the activity of several bioactive peptides, such as endorphins and enkephalins, chemotactic peptides like MCP-1 ...
Erandi Pérez-Figueroa +2 more
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