Results 31 to 40 of about 15,811 (198)

Angiogenic and Arthritogenic Properties of the Soluble Form of CD13 [PDF]

The Journal of Immunology, 2019
Abstract Aminopeptidase N/CD13 is expressed by fibroblast-like synoviocytes (FLS) and monocytes (MNs) in inflamed human synovial tissue (ST). This study examined the role of soluble CD13 (sCD13) in angiogenesis, MN migration, phosphorylation of signaling molecules, and induction of arthritis.
Yuxuan Du, Chenyang Lu, Rachel L Morgan, William A Stinson, Phillip L Campbell, Ellen Cealey, Wenyi Fu, Nicholas J Lepore, Jonatan L Hervoso, Huadong Cui, Andrew G Urquhart, Jeffrey N Lawton, Kevin C Chung, David A Fox, Mohammad A Amin   +14 more
openaire   +2 more sources

Aminopeptidase N (CD13) as a target for cancer chemotherapy [PDF]

Cancer Science, 2011
The enzyme aminopeptidase N (APN, also known as CD13) is a Zn2+ dependent membrane‐bound ectopeptidase that degrades preferentially proteins and peptides with a N‐terminal neutral amino acid. Aminopeptidase N has been associated with the growth of different human cancers and suggested as a suitable target for anti‐cancerous therapy.
Malin, Wickström, Rolf, Larsson, Peter, Nygren, Joachim, Gullbo   +3 more
openaire   +2 more sources

Filamin B and CD13 Are Components of Senescent Secretomes That May Be Involved in Primary (Stress Induced) and Paracrine Senescence of Mesenchymal Stromal Cells

Erciyes Medical Journal, 2019
Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro, Servet Özcan, Nicola Alessio, Mustafa Burak Acar, Giovanni Di Bernardo, Mariarosa Ab Melone, Gianfranco Peluso, Umberto Galderisi   +7 more
doaj   +1 more source

Inactivation of interleukin-8 by aminopeptidase N (CD13) [PDF]

Journal of Leukocyte Biology, 1995
Abstract Aminopeptidase (APN) was found to degrade interleukin-8 (IL-8) and inactivate its chemotactic activity. The chemotactic activity of IL-8 was decreased by APN or neutrophil plasma membranes dose- and time-dependently. The chemotactic activity was not inactivated in the presence of bestatin or WM15 monoclonal antibody.
N, Kanayama, Y, Kajiwara, J, Goto, E, el Maradny, K, Maehara, K, Andou, T, Terao   +6 more
openaire   +2 more sources

Potential therapeutic impact of CD13 expression in non-small cell lung cancer. [PDF]

PLoS ONE, 2017
Aminopeptidase N (CD13) is a zinc-binding protease that has functional effects on both cancerogenesis and tumor angiogenesis. Since CD13 is an antigen suitable for molecular targeted therapies (e.g.
Lars Henning Schmidt, Caroline Brand, Janine Stucke-Ring, Christoph Schliemann, Torsten Kessler, Saliha Harrach, Michael Mohr, Dennis Görlich, Alessandro Marra, Ludger Hillejan, Carsten Müller-Tidow, Georg Lenz, Eva Wardelmann, Rainer Wiewrodt, Wolfgang E Berdel, Christian Schwöppe, Wolfgang Hartmann   +16 more
doaj   +1 more source

CD13 mediates phagocytosis in human monocytic cells [PDF]

Journal of Leukocyte Biology, 2015
Abstract CD13 is a membrane-bound ectopeptidase, highly expressed on monocytes, macrophages, and dendritic cells. CD13 is involved in diverse functions, including degradation of peptide mediators, cellular adhesion, migration, viral endocytosis, signaling, and positive modulation of phagocytosis mediated by FcγRs and other phagocytic ...
Ileana, Licona-Limón, Claudia A, Garay-Canales, Ofelia, Muñoz-Paleta, Enrique, Ortega   +3 more
openaire   +2 more sources

Variable O-glycosylation of CD13 (aminopeptidase N)

Journal of Biological Chemistry, 1991
The monoclonal antibody AG6 was raised against HUVE cells and was confirmed as recognizing CD13 (aminopeptidase N) by its reactivity with the CD13 cDNA transfectant pipz "4". However, in sequential immunoprecipitation studies with another anti-CD13 monoclonal, WM15, neither was able to completely remove the molecules recognized by the other.
P J, O'Connell, V, Gerkis, A J, d'Apice
openaire   +2 more sources

Expression of CD13/Aminopeptidase N by Synovial Fibroblasts: Novel Roles in the Pathogenesis of Rheumatoid Arthritis. [PDF]

, 2014
Aminopeptidase N/CD13 is a metallopeptidase that is highly expressed by fibroblast-like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). The goal of this study was to define CD13 function in the RA joint by monitoring CD13 expression
Morgan, Rachel L.
core   +6 more sources

Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18

Biomolecules, 2023
The β2 integrin CD11b/CD18, also known as complement receptor 3 (CR3), and the moonlighting protein aminopeptidase N (CD13), are two myeloid immune receptors with overlapping activities: adhesion, migration, phagocytosis of opsonized particles, and ...
Laura Díaz-Alvarez, Mariana Esther Martínez-Sánchez, Eleanor Gray, Erandi Pérez-Figueroa, Enrique Ortega   +4 more
doaj   +1 more source

Suppression of CD13 Enhances the Cytotoxic Effect of Chemotherapeutic Drugs in Hepatocellular Carcinoma Cells

Frontiers in Pharmacology, 2021
Multidrug resistance (MDR) of hepatocellular carcinoma (HCC) is a serious problem that directly hinders the effect of chemotherapeutics. In this study, we mainly explore the molecular mechanism of ROS-induced CD13 expression using hepatocarcinoma cells ...
Shengping Ji, Yuqian Ma, Xiaoyan Xing, Binbin Ge, Yutian Li, Xinyue Xu, Jiliang Song, Mei Xiao, Feng Gao, Wenyan Jiang, Chunyan Fang, Xuejian Wang   +11 more
doaj   +1 more source