Results 11 to 20 of about 15,811 (198)
The Role of the Ectopeptidase APN/CD13 in Cancer [PDF]
Biomedicines, 2023 APN/CD13 is expressed in a variety of cells/tissues and is therefore associated with diverse physiological functions, including proliferation, differentiation, migration, angiogenesis, invasion, metastasis, vasoconstriction, and the regulation of normal ...
Uwe Lendeckel +3 more
doaj +4 more sources
Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes. [PDF]
PLoS ONE, 2016 Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthritis ...
Rachel L Morgan +8 more
doaj +2 more sources
CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery [PDF]
Journal of Neuroinflammation, 2023 Introduction Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury.
Justin N. Nguyen +8 more
doaj +2 more sources
A novel aminopeptidase N/CD13 inhibitor selectively targets an endothelial form of CD13 after coupling to proteins [PDF]
Cellular and Molecular Life SciencesAbstractAminopeptidase N/CD13, a membrane-bound enzyme upregulated in tumor vasculature and involved in angiogenesis, can be used as a receptor for the targeted delivery of drugs to tumors through ligand-directed targeting approaches. We describe a novel peptide ligand (VGCARRYCS, called “G4”) that recognizes CD13 with high affinity and selectivity ...
Anderluzzi, Giulia +10 more
openaire +4 more sources
Control of APN/CD13 and NEP/CD10 on sperm motility [PDF]
Asian Journal of Andrology, 2010 Aminopeptidase N (APN/CD13) and neutral endopeptidase (NEP/CD10) are enzymes present in human sperm cells and involved in regulation of sperm motility of noncapacitated spermatozoa. We investigated the involvement of APN/CD13 and NEP/CD10 in motility and in kinematic parameters of human capacitated spermatozoa.
Subiran, Nerea +4 more
openaire +4 more sources
CD105+CD90+CD13+ identifies a clonogenic subset of adventitial lung fibroblasts
Scientific Reports, 2021 Mesenchymal cells are important components of specified niches in the lung, and can mediate a wide range of processes including tissue regeneration and repair.
Måns Kadefors +7 more
doaj +2 more sources
CD13 is a novel mediator of monocytic/endothelial cell adhesion [PDF]
Journal of Leukocyte Biology, 2008 AbstractDuring inflammation, cell surface adhesion molecules guide the adhesion and migration of circulating leukocytes across the endothelial cells lining the blood vessels to access the site of injury. The transmembrane molecule CD13 is expressed on monocytes and endothelial cells and has been shown to mediate homotypic cell adhesion, which may imply
Mina-Osorio, Paola +8 more
openaire +4 more sources
Neutralization of Human Cytomegalovirus by Human CD13-Specific Antibodies [PDF]
Journal of Infectious Diseases, 1996 The mechanisms of inhibition of cytomegalovirus (CMV) infection by human CD13 (aminopeptidase N)-specific antibodies were studied. These antibodies protect CD13-negative and -positive cells from CMV infection only if incubated with the virus inoculum, suggesting they bind to CMV virions.
T D, Giugni +6 more
openaire +3 more sources
Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues [PDF]
iScience, 2023 Summary: Harnessing the differences between cancer and non-cancer tissues presents new opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated protein, is one example with significant unmet clinical potential in cancer ...
Francis M. Barnieh +5 more
doaj +2 more sources
The impact of CD13 on glioma progression
Background: CD13, an aminopeptidase, has been identified as a potential therapeutic target in various cancers. However, its role in gliomas remains largely unexplored. This study aimed to investigate CD13 expression in glioblastoma patients. Furthermore, dif ferent glioma cell lines were analyzed in vitro and in vivo to evaluate the impact of CD13 ...
Zhang, Wenying
core +3 more sources