Results 41 to 50 of about 15,811 (198)

CD13

, 1997
This chapter focuses on the tissue distribution, structure, and functions of the leucocyte antigen CD13. CD13 is expressed by granulocytes and monocytes and their precursors. CD13 is a marker for most acute myeloid leukaemias and a smaller proportion of acute lymphoid leukaemias.
Barclay, A. Neil, Brown, Marion H., Law, S.K. Alex, McKnight, Andrew J., Tomlinson, Michael G., van der Merwe, P. Anton   +5 more
openaire   +1 more source

Bone marrow-derived CD13+ cells sustain tumor progression: A potential non-malignant target for anticancer therapy [PDF]

, 2015
Non-malignant cells found within neoplastic lesions express alanyl (membrane) aminopeptidase (ANPEP, best known as CD13), and CD13-null mice exhibit limited tumor growth and angiogenesis. We have recently demonstrated that a subset of bone marrow-derived
Dondossola, Eleonora, Arap, Wadih, Corti, Angelo, Pasqualini, Renata, Sidman, Richard   +4 more
core   +1 more source

CD13 Restricts TLR4 Endocytic Signal Transduction in Inflammation [PDF]

The Journal of Immunology, 2015
Abstract Dysregulation of the innate immune response underlies numerous pathological conditions. The TLR4 is the prototypical sensor of infection or injury that orchestrates the innate response via sequential activation of both cell surface and endocytic signaling pathways that trigger distinct downstream consequences.
Mallika, Ghosh, Jaganathan, Subramani, M Mamunur, Rahman, Linda H, Shapiro   +3 more
openaire   +2 more sources

Novel, Aberrantly Truncated Isoform of Serum CD13 in a Family with High Serum Aminopeptidase N (CD13) Activity

Clinical Chemistry, 2001
AbstractBackground: We previously reported a family in which the propositus and both her father and paternal grandmother had high serum aminopeptidase N (CD13; EC 3.4.11.2) activity (autosomal dominant). The molecular mass of the serum CD13 polypeptide of the propositus was larger than that of normal CD13, suggesting either a mutation in the CD13 gene ...
M, Kawai, Y, Hara, I, Miyazato, S, Hosaki   +3 more
openaire   +2 more sources

An antimicrobial peptide containing NGR motif has potent antitumor activity against CD13+ and CD13− tumor cells

Tumor Biology, 2015
Antimicrobial peptides (AMPs) with Asn-Gly-Arg (NGR) motif have potent cytotoxicity, preferably against tumor cells due to their binding to CD13 on tumor cells. However, the importance of αvβ3 expression for antitumor activity of AMPs containing NGR has not been clarified.
Zhe, Zhang, Lei, Hou, Lu, Feng, Shangke, Huang, Minna, Luo, Shan, Shao, Xiaojin, Zhang, Shanzhi, Gu, Xinhan, Zhao   +8 more
openaire   +2 more sources

Promoter methylation of aminopeptidase N/CD13 in malignant melanoma [PDF]

Carcinogenesis, 2012
Aminopeptidase N (APN)/CD13 as ubiquitously expressed membrane peptidase exerts important functions in diverse cellular processes, such as proliferation, migration and differentiation. Previously, a role of APN in the invasiveness of melanoma cells has been demonstrated, but the underlying molecular mechanisms controlling APN expression are not ...
Wulfänger, Jens, Schneider, Heike, Wild, Peter, Ikenberg, Kristian, Rodolfo, Monica, Rivoltini, Licia, Meyer, Stefanie, Riemann, Dagmar, Seliger, Barbara   +8 more
openaire   +4 more sources

Acquisition of CD13 and CD33 Expression at Relapse on Acute Myeloid Leukemia Cells with an Unusual Phenotype: MPO+CD13-CD33-.

Internal Medicine, 1993
A case of acute myeloid leukemia (AML) with an unusual phenotype which was negative for a panel of myeloid antigens determined by flow cytometry, but was strongly positive for myeloperoxidase has recently been reported. We herein describe a case of AML with this unusual phenotype at diagnosis; relapse occurred with the acquisition of CD13 and CD33 ...
KAWADA, Hiroshi, ICHIKAWA, Yukinobu, KOBAYASHI, Nobumasa, FUKUDA, Ryuki, YONEKURA, Shuji, NAGAO, Tadami   +5 more
openaire   +3 more sources

Aminopeptidase N (CD13): Expression, Prognostic Impact, and Use as Therapeutic Target for Tissue Factor Induced Tumor Vascular Infarction in Soft Tissue Sarcoma

Translational Oncology, 2018
Aminopeptidase N (CD13) is expressed on tumor vasculature and tumor cells. It represents a candidate for targeted therapy, e.g., by truncated tissue factor (tTF)-NGR, binding to CD13, and causing tumor vascular thrombosis.
Torsten Kessler, Ariane Baumeier, Caroline Brand, Michael Grau, Linus Angenendt, Saliha Harrach, Ursula Stalmann, Lars Henning Schmidt, Georg Gosheger, Jendrik Hardes, Dimosthenis Andreou, Johannes Dreischalück, Georg Lenz, Eva Wardelmann, Rolf M. Mesters, Christian Schwöppe, Wolfgang E. Berdel, Wolfgang Hartmann, Christoph Schliemann   +18 more
doaj   +1 more source

Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

, 2014
International audienceSecreted matrix metalloproteinases (MMP)-2 and MMP-9 and membrane-anchored aminopeptidase-N/CD13 are abnormally expressed in human acute myeloid leukaemia (AML).
Bauvois, Brigitte, Tang, Ruoping, Legrand, Ollivier, Fava, Fanny, Bouchet, Sandrine   +4 more
core   +1 more source

Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion

, 2018
CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.).
Enrique Ortega, Ileana Licona-Limón, Claudia A. Garay-Canales   +2 more
core   +1 more source