Results 61 to 70 of about 15,811 (198)

A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells

Acta Pharmaceutica Sinica B, 2017
Previously developed Asn-Gly-Arg (NGR) peptide-modified multifunctional poly(ethyleneimine)–poly(ethylene glycol) (PEI–PEG)-based nanoparticles (TPIC) have been considered to be promising carriers for the co-delivery of DNA and doxorubicin (DOX).
Chunxi Liu, Tingxian Liu, Xiaoyue Yu, Yizhu Gu   +3 more
doaj   +1 more source

Clinical applications of CD34+ progenitor cell immunophenotyping in myelodysplastic neoplasms—The CytHem SMD French network experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a risk of progression to acute myeloid leukemia. As the disease originates in hematopoietic stem and progenitor cells (HSPCs), flow cytometry (FCM) has emerged as a key approach to interrogate the bone ...
Nicolas Chapuis, Anne‐Catherine Lhoumeau, Stéphanie Mathis, Michel Ticchioni, Valérie Bardet, the French Working Group CytHem‐SMD   +5 more
wiley   +1 more source

Flow Cytometry‐Guided Diagnosis of Cortical T‐Lymphoblastic Lymphoma Presenting With a Massive Mediastinal Mass and Borderline Bone Marrow Involvement

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background T‐cell lymphoblastic lymphoma (T‐LBL) and T‐cell acute lymphoblastic leukemia (T‐ALL) are considered a single biological entity, distinguished primarily by the extent of bone marrow infiltration. This distinction becomes diagnostically challenging in patients with borderline marrow blast counts and predominantly extramedullary ...
Chen Glait‐Santar, Yakir Moshe, Itzhaki‐Alfia Ayelet, Ben‐Zion Katz   +3 more
wiley   +1 more source

Aminopeptidase N/CD13 as a potential therapeutic target in malignant pleural mesothelioma

, 2018
Angiogenesis is a crucial factor in the progression of malignant pleural mesothelioma (MPM) and antiangiogenic strategies might be effective against MPM.
Shin Akita, Takeshi Masuda, Yasushi Horimasu, Shintaro Miyamoto, Nobuoki Kohno, Taku Nakashima, Hironobu Hamada, Morihito Okada, Noboru Hattori, Takahiko Otsuki, Kazunori Fujitaka, Yusuke Takayama, Yoshihiro Miyata, Masayuki Miyake, Hiroshi Iwamoto   +14 more
core   +1 more source

ESTUDO RETROSPECTIVO DO FENÓTIPO DAS LEUCEMIAS AGUDAS “EARLY PRÉ-T” NO ESTADO DE SANTA CATARINA

Hematology, Transfusion and Cell Therapy, 2023
Objetivos: descrição dos casos de leucemias “Early Pre-T” no Estado de Santa Catarina. Resultados: De 01 de abril de 2019 a 30 de março de 2023, no Laboratório de Marcadores Celulares do Hemosc foram diagnosticados 517 novos casos de Leucemias Agudas ...
MDH Périco, RS Kalfeltz, AOM Wagner, AO Ferri, FC Delagnello, LC Bortoluzzi, PGB Prim   +6 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source

CD13 is upregulated in FLS at the mRNA level but the effects on CD13 protein levels are varied.

, 2016
FLS were stimulated over a time course of 0–72 hours with IFNγ (1000U/ml), TNFα (10ng/ml), or IL-17 (10ng/ml). Cells were harvested and processed for either mRNA (A), surface expression (B), total cell lysate CD13 (C), or total CD13 in supernatant (D ...
Kevin C. Chung (3132753), Nick J. Lepore (3132738), David A. Fox (441429), Judith Endres (3132741), Rachel L. Morgan (3132747), M. Asif Amin (3132744), Yuxuan Du (3132735), Andrew Urquhart (3132750), Nilofar Behbahani-Nejad (3132756)   +8 more
core   +1 more source

CD13 and ROR2 Permit Isolation of Highly Enriched Cardiac Mesoderm from Differentiating Human Embryonic Stem Cells

Stem Cell Reports, 2016
The generation of tissue-specific cell types from human embryonic stem cells (hESCs) is critical for the development of future stem cell-based regenerative therapies.
Rhys J.P. Skelton, Bevin Brady, Suhail Khoja, Debashis Sahoo, James Engel, Deevina Arasaratnam, Kholoud K. Saleh, Oscar J. Abilez, Peng Zhao, Edouard G. Stanley, Andrew G. Elefanty, Murray Kwon, David A. Elliott, Reza Ardehali   +13 more
doaj   +1 more source