Results 81 to 90 of about 15,811 (198)

Acute Promyelocytic Leukemia With PML‐RARA Rearrangement: Clinical and Morphologic Features

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Recognition of the characteristic morphologic features of acute promyelocytic leukemia on peripheral blood smear should prompt immediate initiation of all‐trans retinoic acid while awaiting confirmatory testing, as early intervention is critical to reducing hemorrhagic mortality and improving clinical outcomes.
Chukwuka Elendu, Ayodeji D. Johnson, Ayi T. Debua   +2 more
wiley   +1 more source

Lineage switch in childhood leukemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Lineage switch (LS) is a rare but aggressive immunophenotypic transformation of acute leukemia associated with limited therapeutic options and poor clinical outcome. Although LS has been increasingly recognized in the era of CD19‐directed immunotherapies, its biological basis remains incompletely understood.
Katharina Daugs, Anna Prazmo, Anindita Roy, Arndt Borkhardt   +3 more
wiley   +1 more source

Aminopeptidase‐N/CD13 is a potential proapoptotic target in human myeloid tumor cells

, 2011
International audienceThe transmembrane metalloprotease aminopeptidase-N (APN)/CD13 is overexpressed in various solid and hematological malignancies in humans, including acute myeloid leukemia (AML) and is thought to influence tumor progression. Here, we
Brigitte Bauvois, Bauvois, Brigitte, Marion Piedfer, Dauzonne, Daniel, Ruoping Tang, Piedfer, Marion, Juliette N'Guyen, Daniel Dauzonne, Tang, Ruoping, N'Guyen, Juliette, Billard, Christian, Christian Billard   +11 more
core   +1 more source

The DNA repair kinase ATM regulates CD13 expression and cell migration

Frontiers in Cell and Developmental Biology
Classically, ATM is known for its role in sensing double-strand DNA breaks, and subsequently signaling for their repair. Non-canonical roles of ATM include transcriptional silencing, ferroptosis, autophagy and angiogenesis.
Louise K. Stevenson, Louise K. Stevenson, Amy J. Page, Matthew Dowson, Sameh K. ElBadry, Francis M. Barnieh, Robert A. Falconer, Sherif F. El-Khamisy, Sherif F. El-Khamisy   +8 more
doaj   +1 more source

Identification of a candidate stem cell in human gallbladder

Stem Cell Research, 2015
There are currently no reports of identification of stem cells in human gallbladder. The differences between human gallbladder and intrahepatic bile duct (IHBD) cells have also not been explored.
Rohan Manohar, Yaming Li, Helene Fohrer, Lynda Guzik, Donna Beer Stolz, Uma R. Chandran, William A. LaFramboise, Eric Lagasse   +7 more
doaj   +1 more source

NLRP3 Is Involved in the Maintenance of Cerebral Pericytes

Frontiers in Cellular Neuroscience, 2020
Pericytes play a central role in regulating the structure and function of capillaries in the brain. However, molecular mechanisms that drive pericyte proliferation and differentiation are unclear. In our study, we immunostained NACHT, LRR and PYD domains-
Wenqiang Quan, Wenqiang Quan, Qinghua Luo, Qiqiang Tang, Tomomi Furihata, Dong Li, Klaus Fassbender, Yang Liu, Yang Liu   +8 more
doaj   +1 more source

Adipose‐Derived Mesenchymal Stem Cells: Isolation, Origin, Phenotype Applications, and Challenges

MedComm, Volume 7, Issue 11, November 2026.
Bridging basic biology to clinical translation, this review systematically explores the in vivo origins and evolving isolation techniques of AD‐MSCs. We dissect their diverse phenotype applications orchestrated by immunometabolic reprogramming, mitochondrial transfer, and extracellular vesicles.
Ziyang Liu, Guangming Tu, Chao Wang, Hongyan Zhao, Ziyi Wu, Wei Li, Li Chen, Bailin Niu   +7 more
wiley   +1 more source

Probable Stevens–Johnson Syndrome During Taletrectinib Treatment After Crizotinib‐Related Rash in ROS1‐Positive Lung Cancer

Respirology Case Reports, Volume 14, Issue 11, November 2026.
Probable Stevens–Johnson syndrome developed during taletrectinib treatment after a preceding crizotinib‐related Grade 3 rash in a patient with ROS1‐rearranged lung adenocarcinoma. This case highlights that severe cutaneous adverse reactions should be considered when fever and neutropenia occur during ROS1‐TKI therapy.
Hirotoshi Yasui, Ryo Fukaura, Miyu Misaki, Souma Usui, Saho Katsumata, Ryo Niimi, Ko Ohara, Kaito Sano, Yasutaka Mori, Tomofumi Shibata, Yasutaka Fukui, Mitsuru Odate, Yasushi Makino   +12 more
wiley   +1 more source

Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization

Cell Reports
Summary: Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the ...
Leire Bejarano, Alberto Hernández-Barranco, Vincent Roh, Rui Santalla Méndez, Eleni Lamprou, Catia F. Costa, Michelle Ballabio, Monika E. Hegi, Nadine Fournier, Johanna A. Joyce   +9 more
doaj   +1 more source

A rare case of de novo CD5+ diffuse large B-cell lymphoma in leukemic phase and positive for CD13

Hematology Reports, 2018
We report a case of de novo diffuse large B-cell lymphoma (DLBCL) in leukemic phase, positive for both CD5 and CD13. Morphologic evaluation, flow cytometric immunophenotyping, karyotyping and polymerase chain reaction studies were performed.
Giovanni Carulli, Eugenio Mario Ciancia, Francesco Caracciolo, Paola Sammuri, Cristiana Domenichini, Maria Immacolata Ferreri, Alessia Di Vita, Virginia Ottaviano, Martina Rousseau, Mario Petrini   +9 more
doaj   +1 more source