Results 21 to 30 of about 15,811 (198)
Cancer Medicine, 2023 Background Cross‐lineage expression of the myeloid‐associated antigens CD13/CD33 is common in adult B‐lymphoblastic leukemia (B‐ALL) patients, yet its prognostic value is still controversial.
Hongyan Liao +7 more
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Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells [PDF]
BMC Cancer, 2007 Background Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression. Recent studies have suggested that APN/CD13 plays an important role in tumor progression of several human ...
Mizutani Shigehiko +6 more
doaj +3 more sources
CD13 is a critical regulator of cell–cell fusion in osteoclastogenesis [PDF]
Scientific Reports, 2021 The transmembrane aminopeptidase CD13 is highly expressed in cells of the myeloid lineage, regulates dynamin-dependent receptor endocytosis and recycling and is a necessary component of actin cytoskeletal organization.
Mallika Ghosh +4 more
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CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110 [PDF]
Journal of Hematology & Oncology, 2020 Background In the search for novel antibody-drug conjugates (ADCs) with therapeutic potential, it is imperative to identify novel targets to direct the antibody moiety.
Juan Manuel Domínguez +12 more
doaj +2 more sources
The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion. [PDF]
PLoS ONE, 2016 Aminopeptidase N (CD13) is a widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells. Apart from our demonstration that CD13 modulates the efficacy of tumor necrosis factor-α-induced apoptosis in ...
Christine A Fiddler +6 more
doaj +4 more sources
CD13 regulation of membrane recycling: implications for cancer dissemination [PDF]
Molecular & Cellular Oncology, 2019 Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif ...
Mallika Ghosh, Linda H. Shapiro
doaj +3 more sources
Enhanced Expression of CD13 in Vessels of Inflammatory and Neoplastic Tissues [PDF]
Journal of Histochemistry & Cytochemistry, 2010 Aminopeptidase-N (CD13) is an important target of tumor vasculature-targeting drugs. The authors investigated its expression by immunohistochemistry with three anti-CD13 monoclonal antibodies (WM15, 3D8, and BF10) in normal and pathological human tissues, including 58 normal, 32 inflammatory, and 149 tumor tissue specimens. The three antibodies stained
Di Matteo P +7 more
openaire +4 more sources
OncoImmunologyAdoptive cell therapy including chimeric antigen receptor (CAR) T cells targeting CD19 has been approved by FDA to treat B cell-derived malignancies with remarkable success.
Xuyao Zhang +3 more
doaj +2 more sources
CD13 in cell adhesion: aminopeptidase N (CD13) mediates homotypic aggregation of monocytic cells [PDF]
Journal of Leukocyte Biology, 2006 Abstract Homotypic aggregation (HA) of cells plays key roles in physiological and pathological processes, such as embryogenesis, immune responses, angiogenesis, tumor cell invasion, and metastasis. Aminopeptidase N (CD13) has been implicated in most of these phenomena, although its participation has been attributed to its enzymatic ...
Paola, Mina-Osorio +2 more
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CD13/aminopeptidase N in collagen vascular diseases [PDF]
Rheumatology International, 2003 To determine the significance of CD13/aminopeptidase N in collagen vascular diseases (CVD), we examined its activity and expression in sera and disease sites of patients with CVD. Significantly higher aminopeptidase activity was detected in bronchoalveolar lavage fluid from patients with interstitial lung diseases due to rheumatoid arthritis (RA ...
Dan, Hirohumi +8 more
openaire +2 more sources