Preparation and Epitope Identification of Monoclonal Antibodies Against the NS6 Protein of Porcine Deltacoronavirus (PDCoV) [PDF]
International Journal of Molecular SciencesPorcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that causes substantial economic losses in the swine industry worldwide. The PDCoV NS6 protein is an accessory protein that plays a pivotal role in the viral life cycle and immune evasion. However, the functions of NS6 and its role in PDCoV pathogenesis remain largely unknown.
Huiguang Wu, Zhenhai Chen
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Porcine Deltacoronavirus (PDCoV) Modulates Calcium Influx to Favor Viral Replication [PDF]
Virology, 2020 Ionic calcium (Ca2+) is a versatile intracellular second messenger that plays important roles in cellular physiological and pathological processes. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes serious vomiting and diarrhea in suckling piglets.
Shaobo Xiao, Liurong Fang, Puxian Fang
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The Use of Cells From ANPEP Knockout Pigs to Evaluate the Role of Aminopeptidase N (APN) as a Receptor for Porcine Deltacoronavirus (PDCoV) [PDF]
Virology, 2020 The coronaviruses, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) represent important sources of neonatal diarrhea on pig farms. The requirement for aminopeptidase N (APN) as a receptor for TGEV, but not for PEDV, is well established.
Jianqiang Zhang +2 more
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Structures of a deltacoronavirus spike protein bound to porcine and human receptors
Nature Communications, 2022 Porcine deltacoronavirus (PDCoV) can experimentally infect a variety of animals. Human infection by PDCoV has also been reported. Consistently, PDCoV can use aminopeptidase N (APN) from different host species as receptors to enter cells.
Weiwei Ji +13 more
doaj +2 more sources
Herd-Level Prevalence and Incidence of Porcine Epidemic Diarrhoea Virus (PEDV) and Porcine Deltacoronavirus (PDCoV) in Swine Herds in Ontario, Canada [PDF]
Transboundary and Emerging Diseases, 2018 Porcine epidemic diarrhoea virus (PEDV) and porcine deltacoronavirus (PDCoV) were first identified in Canada in 2014. Surveillance efforts have been instrumental in controlling both diseases. In this study, we provide an overview of surveillance components for the two diseases in Ontario (Canada), as well as PEDV and PDCoV incidence and prevalence ...
Rozita Dara, Toluwalope Ajayi, Z Poljak
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Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine. [PDF]
Vet Res, 2021 AbstractPorcine deltacoronavirus (PDCoV) is a newly discovered swine enteropathogenic coronavirus with worldwide distribution. However, efficient strategies to prevent or treat the infection remain elusive. Our in vitro study revealed that ergosterol peroxide (EP) from the mushroom Cryptoporus volvatus has efficient anti-PDCoV properties.
Duan C +6 more
europepmc +6 more sources
Pathogens, 2019 Porcine deltacoronavirus (PDCoV) is an emerging global swine virus that has a propensity for interspecies transmission. It was identified in Hong Kong in 2012.
Xiaofeng Zhai +5 more
doaj +2 more sources
Rapid Detection, Complete Genome Sequencing, and Phylogenetic Analysis of Porcine Deltacoronavirus
Emerging Infectious Diseases, 2014 In February 2014, porcine deltacoronavirus (PDCoV) was identified in the United States. We developed a PDCoV real-time reverse transcription PCR that identified PDCoV in 30% of samples tested.
Douglas Marthaler +5 more
doaj +2 more sources
Pathogens, 2022 Porcine deltacoronavirus (PDCoV), belonging to family Coronaviridae and genus Deltacoronavirus, is a major enteric pathogen in swine. Accurate PDCoV diagnosis relying on laboratory testing and antibody detection is an important approach.
Lu Yen +10 more
doaj +2 more sources
Pathogenicity of Porcine Deltacoronavirus (PDCoV) Strain NH and Immunization of Pregnant Sows With an Inactivated PDCoV Vaccine Protects 5-Day-Old Neonatal Piglets From Virulent Challenge [PDF]
Transboundary and Emerging Diseases, 2020 In this study, the pathogenicity of porcine deltacoronavirus (PDCoV) strain NH (passage 10, P10) was evaluated. We found that PDCoV strain NH is enteropathogenic in 5-day-old pigs. Pathogenicity experiments provided a challenge model for studying the protection efficiency of passive immunity.
Liyan Cao
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