Results 11 to 20 of about 1,933 (170)

Ergosterol peroxide exhibits antiviral and immunomodulatory abilities against porcine deltacoronavirus (PDCoV) via suppression of NF-κB and p38/MAPK signaling pathways in vitro. [PDF]

Int Immunopharmacol, 2021
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that poses economic and public health burdens. Currently, there are no effective antiviral agents against PDCoV. Cryptoporus volvatus often serves as an antimicrobial agent in Traditional Chinese Medicines.
Duan C, Ge X, Wang J, Wei Z, Feng WH, Wang J.   +5 more
europepmc   +5 more sources

The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV). [PDF]

Virology, 2020
The coronaviruses, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) represent important sources of neonatal diarrhea on pig farms. The requirement for aminopeptidase N (APN) as a receptor for TGEV, but not for PEDV, is well established.
Stoian A, Rowland RRR, Petrovan V, Sheahan M, Samuel MS, Whitworth KM, Wells KD, Zhang J, Beaton B, Cigan M, Prather RS.   +10 more
europepmc   +5 more sources

Herd-level prevalence and incidence of porcine epidemic diarrhoea virus (PEDV) and porcine deltacoronavirus (PDCoV) in swine herds in Ontario, Canada. [PDF]

Transbound Emerg Dis, 2018
Porcine epidemic diarrhoea virus (PEDV) and porcine deltacoronavirus (PDCoV) were first identified in Canada in 2014. Surveillance efforts have been instrumental in controlling both diseases. In this study, we provide an overview of surveillance components for the two diseases in Ontario (Canada), as well as PEDV and PDCoV incidence and prevalence ...
Ajayi T, Dara R, Misener M, Pasma T, Moser L, Poljak Z.   +5 more
europepmc   +6 more sources

Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production. [PDF]

Virology, 2016
Porcine deltacoronavirus (PDCoV), an emerging animal coronavirus causing enteric disease in pigs, belongs to the newly identified Deltacoronavirus genus in the Coronaviridae family. Although extensive studies have been carried out to investigate the regulation of interferon (IFN) responses by alphacoronaviruses, betacoronaviruses, and ...
Luo J, Fang L, Dong N, Fang P, Ding Z, Wang D, Chen H, Xiao S.   +7 more
europepmc   +5 more sources

Pathogenicity of porcine deltacoronavirus (PDCoV) strain NH and immunization of pregnant sows with an inactivated PDCoV vaccine protects 5-day-old neonatal piglets from virulent challenge. [PDF]

Transbound Emerg Dis, 2020
In this study, the pathogenicity of porcine deltacoronavirus (PDCoV) strain NH (passage 10, P10) was evaluated. We found that PDCoV strain NH is enteropathogenic in 5-day-old pigs. Pathogenicity experiments provided a challenge model for studying the protection efficiency of passive immunity.
Zhang J, Chen J, Liu Y, Da S, Shi H, Zhang X, Liu J, Cao L, Zhu X, Wang X, Ji Z, Feng L.   +11 more
europepmc   +6 more sources

Preparation and Epitope Identification of Monoclonal Antibodies against the NS6 Protein of Porcine Deltacoronavirus (PDCoV). [PDF]

Int J Mol Sci
Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that causes substantial economic losses in the swine industry worldwide. The PDCoV NS6 protein is an accessory protein that plays a pivotal role in the viral life cycle and immune evasion. However, the functions of NS6 and its role in PDCoV pathogenesis remain largely unknown.
Wu H, Sun X, Li C, Xie S, Chen Z.
europepmc   +3 more sources

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination [PDF]

Frontiers in Immunology, 2019
Porcine deltacoronavirus (PDCoV) is a newly detected porcine coronavirus causing serious vomiting and diarrhea in piglets, especially newborn piglets. There has been an outbreak of PDCoV in worldwide since 2014, causing significant economic losses in the
Ji Likai, Li Shasha, Zhu Wenxian, Ma Jingjiao, Sun Jianhe, Wang Hengan, Yan Yaxian   +6 more
doaj   +3 more sources

Microbial Community and Metabolome Analysis of the Porcine Intestinal Damage Model Induced by the IPEC-J2 Cell Culture-Adapted Porcine Deltacoronavirus (PDCoV) Infection. [PDF]

Microorganisms
This study was conducted to elucidate the intestinal damage induced by the IPEC-J2 cell culture-passaged PDCoV. The results showed that PDCoV disrupted the intestinal structure and increased intestinal permeability, causing abnormalities in mucosal pathology.
Shi Y, Li B, Cheng J, Tao J, Tang P, Jiao J, Liu H.   +6 more
europepmc   +4 more sources

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) of Porcine deltacoronavirus (PDCoV) Elicit Robust Protective Immune Responses in mice

, 2023
Abstract Background Porcine deltacoronavirus (PDCoV), a novel swine enteropathogenic coronavirus, that causes acute diarrhea, vomiting, dehydration and mortality in neonatal piglets, resulting in significant economic losses to the swine industry worldwide. At present, there are no effective prevention and control measures for PDCoV.
Wang Y, Song J, Wang J, zhang M, Liu Y, Tang P, Huili L, Zhou Y, Tong G, Yu L, Li G, Deng X.   +11 more
europepmc   +2 more sources

Development and application of an ELISA for the detection of porcine deltacoronavirus IgG antibodies. [PDF]

PLoS ONE, 2015
Porcine deltacoronavirus (PDCoV), also known as porcine coronavirus HKU15, was first detected in North America in early 2014 and associated with enteric disease in pigs, resulting in an urgent need to further investigate the ecology of this virus.
Anil Thachil, Priscilla F Gerber, Chao-Ting Xiao, Yao-Wei Huang, Tanja Opriessnig   +4 more
doaj   +5 more sources