Results 71 to 80 of about 3,368 (205)

CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

eLife, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production.
Kui Xu, Yanrong Zhou, Yulian Mu, Zhiguo Liu, Shaohua Hou, Yujian Xiong, Liurong Fang, Changli Ge, Yinghui Wei, Xiuling Zhang, Changjiang Xu, Jingjing Che, Ziyao Fan, Guangming Xiang, Jiankang Guo, Haitao Shang, Hua Li, Shaobo Xiao, Julang Li, Kui Li   +19 more
doaj   +1 more source

Recent Advances in Lateral Flow Immunoassay for Rapid Diagnosis of Viral Diseases

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Viral diseases are a major threat to human and animal health, as illustrated by recent pandemics like COVID‐19 and African swine fever (ASF). Timely, accurate detection of viral infections is critical for effective disease control. Among diverse diagnostic techniques, lateral flow immunoassay (LFIA) has become a widely used on‐site testing tool, owing ...
Quanyu Ren, Yan Wang, Haoyuan Ma, Jialiang Xie, Jianyou Jin, Rumeng Tian, Hao Yu, Xu Gao, Nanhua Chen   +8 more
wiley   +1 more source

Detection of swine emerging viruses by Real-time PCR and histopathological examination of tissue lesions in domestic pigs (Sus scrofa domesticus) in Sardinia [PDF]

, 2023
Population growth leads to global meat consumption and production increase. In Italy, pork production plays an important economic role. In Sardinia, pork-producing farms are familiar, and intensive farms are uncommon.
HAWKO, SALWA
core  

The Tetrahydroisoquinoline Derivative SP9 Exhibits Antiviral Activity Against PEDV and MHV

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Coronaviruses exhibit high mutation rates and cross‐species transmissibility, posing a persistent threat to human and animal health and underscoring the urgent need for antivirals that can compensate for the limited crossprotection afforded by current vaccines.
Junhai Zhu, Yuting Jiang, Kaifang Yang, Fei Gao, Wenbao Qi, Lihong Huang, Yue Wang, Bin Li   +7 more
wiley   +1 more source

Coronaviruses: a review of their properties and diversity [PDF]

, 2020
Human coronaviruses, which hitherto were causative agents of mild respiratory diseases of man, have recently become one of the most important groups of pathogens of humans the world over. In less than two decades, three members of the group, severe acute
Fagbami, A.H., Joseph, A.A.
core   +2 more sources

A Novel Adjuvant System for High‐Efficiency Subunit Vaccines Against Porcine Deltacoronavirus

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Summary The immunopotentiation efficacy of polydimethyl diallyl ammonium chloride (pDMDAAC) nanoparticles (NPs) as an adjuvant for the spike (S) protein subunit vaccine of porcine deltacoronavirus (PDCoV) was investigated, with particular emphasis on the combination of the NPs with the STING agonist cGAMP.
Shuangyuan Xu, Shuqing Zhao, Ziyi Niu, Xiaofeng Xue, Wei Wang, Rongli Guo, Lili Ren, Bin Li, Jizong Li, Linzhu Ren   +9 more
wiley   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

iMeta, Volume 4, Issue 5, October 2025.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang, Bin Wang, Yong‐Le Yang, Jin‐Xin Meng, Meng‐Di Zhang, Yi‐Ke Li, Bo Dong, Yanan Zhang, Bo‐Wen Liu, Dong Yang, Chun‐Miao Ji, Yao‐Wei Huang, Shu Jeffrey Zhu   +12 more
wiley   +1 more source

The neighborhood of the Spike gene is a hotspot for modular intertypic homologous and non-homologous recombination in Coronavirus genomes. [PDF]

, 2021
Coronaviruses (CoVs) have very large RNA viral genomes with a distinct genomic architecture of core and accessory open reading frames (ORFs).
Amoutzias, Grigorios D, Markoulatos, Panayotis, Nikolaidis, Marios, Oliver, Stephen G, Van de Peer, Yves   +4 more
core   +3 more sources

Exomeres From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promote Vascular Remodelling via Transferring Osteopontin

Journal of Extracellular Vesicles, Volume 14, Issue 8, August 2025.
ABSTRACT Vascular adventitial fibroblasts (VAFs) contribute to vascular remodelling in hypertension. However, the mechanisms by which VAFs regulate vascular smooth muscle cells (VSMCs) in vascular remodelling are not well known. Here we report the crucial roles of extracellular nanoparticles exomeres (EMs) derived from VAFs in promoting VSMCs ...
Jing‐Xiao Wang, Xiao‐Yu Xu, Hong‐Ke Dong, Yi‐Ming Wang, Min Dai, Bing Zhou, Yue‐Hua Li, Guo‐Qing Zhu, Xiao‐Qing Xiong   +8 more
wiley   +1 more source

Genetic characterization of the first Deltacoronavirus from wild birds around Qinghai Lake

Frontiers in Microbiology
Deltacoronavirus, widely distributed among pigs and wild birds, pose a significant risk of cross-species transmission, including potential human epidemics.
Ye Tian, Tianqi Yu, Jun Wang, Haoxiang Zhang, Yingna Jian, Xiuping Li, Geping Wang, Guanghua Wang, Yong Hu, Chenhe Lu, Jiyong Zhou, Liqing Ma, Min Liao   +12 more
doaj   +1 more source