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Construction of subunit vaccine by fusing Salmonella flagellin with neutralizing epitopes of porcine epidemic diarrhea virus [PDF]

Frontiers in Veterinary Science
IntroductionTo address practical application and production demands, this study aims to develop a Porcine epidemic diarrhea (PED) subunit vaccine with high expression efficiency and immunogenicity, using molecular biology and structural biology ...
Xudong Gao, Yuanfang Rao, Aiqing Jia, Aiqing Jia, Aiqing Jia, Guiping Wang, Guiping Wang, Guiping Wang, Jinming Cui, Jinming Cui, Jinming Cui   +10 more
doaj   +2 more sources

Porcine Epidemic Diarrhea in Europe: In-Detail Analyses of Disease Dynamics and Molecular Epidemiology

Viruses, 2017
Porcine epidemic diarrhea (PED) is an acute and highly contagious enteric disease of swine caused by the eponymous virus (PEDV) which belongs to the genus Alphacoronavirus within the Coronaviridae virus family.
Sandra Blome, Dirk Höper, Martin Beer
exaly   +3 more sources

Magnolol inhibits porcine epidemic diarrhea virus infection by suppressing cathepsin L expression in vitro and in vivo [PDF]

Journal of Virology
Porcine epidemic diarrhea (PED), caused by the porcine epidemic diarrhea virus (PEDV), is an acute and highly contagious intestinal disease in pigs. The high variability of the PEDV S gene has rendered current commercial vaccines ineffective, indicating ...
Yi-fan Liang, Xi Li, Gao-xi Zhu, Yi Song, Xiong-nan Chen, Heng Wang, Gui-hong Zhang   +6 more
doaj   +2 more sources

How Does Porcine Epidemic Diarrhea Virus Escape Host Innate Immunity? [PDF]

Pathogens
Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea (PED), induces vomiting, watery diarrhea, and severe dehydration in pigs. It exhibits particularly high lethality in neonatal piglets, posing a significant threat to
Jinyuan Li, Hao Lu, Gaowei Hu, Shengmei Pang, Yuqing Xie, Guoqiang Zhu, Xueyan Ding   +6 more
doaj   +2 more sources

Study on the antibody level differences of ped igg and iga, tge igg and por igg after immunization with different porcine viral diarrhea vaccine combinations [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
To prevent porcine viral diarrhea, a vaccine combination that can provide good antibody levels needs to be determined. In this study, we screened 30 pregnant sows divided into six experimental groups, namely, five immunized groups and one control group ...
Qiu-yong CHEN, Ru-jing CHEN, Xue-min WU, Yong-liang CHE, Bo HOU, Chen-yan WANG, Long-bai WANG, Lun-jiang ZHOU   +7 more
doaj   +1 more source

The New Porcine Epidemic Diarrhea Virus Outbreak May Mean That Existing Commercial Vaccines Are Not Enough to Fully Protect Against the Epidemic Strains

Frontiers in Veterinary Science, 2021
Background: On October 30, 2020, piglets and sows in the farrowing house of a pig farm in Jiangxi showed clinical symptoms such as anorexia, watery diarrhea, and vomiting.
Qi Gao, Zezhong Zheng, Zezhong Zheng, Heng Wang, Heng Wang, Heng Wang, Songqiang Yi, Guihong Zhang, Guihong Zhang, Guihong Zhang, Guihong Zhang, Lang Gong, Lang Gong   +12 more
doaj   +1 more source

Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus

Frontiers in Microbiology, 2022
Host’s innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity.
Kunli Zhang, Kunli Zhang, Sen Lin, Jianhao Li, Shoulong Deng, Jianfeng Zhang, Jianfeng Zhang, Sutian Wang   +7 more
doaj   +1 more source

A Novel Pathogenic Mammalian Orthoreovirus from Diarrheic Pigs and Swine Blood Meal in the United States

mBio, 2015
Since May 2013, outbreaks of porcine epidemic diarrhea have devastated the U.S. swine industry, causing immense economic losses. Two different swine enteric coronaviruses (porcine epidemic diarrhea virus and Delta coronavirus) have been isolated from the
Athmaram Thimmasandra Narayanappa, Harini Sooryanarain, Jagadeeswaran Deventhiran, Dianjun Cao, Backiyalakshmi Ammayappan Venkatachalam, Devaiah Kambiranda, Tanya LeRoith, Connie Lynn Heffron, Nicole Lindstrom, Karen Hall, Peter Jobst, Cary Sexton, Xiang-Jin Meng, Subbiah Elankumaran   +13 more
doaj   +1 more source

A Review of Bioactive Compounds against Porcine Enteric Coronaviruses

Viruses, 2022
Pig diarrhea is a universal problem in the process of pig breeding, which seriously affects the development of the pig industry. Porcine enteric coronaviruses (PECoVs) are common pathogens causing diarrhea in pigs, currently including transmissible ...
Cong Duan, Yufeng Luo, Xianming Liang, Xia Wang   +3 more
doaj   +1 more source

Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan

Virology Journal, 2018
Background Porcine epidemic diarrhea (PED) is a lethal infectious disease in suckling piglets with symptoms including watery diarrhea caused by PED virus (PEDV). Since the late 1990’s, live vaccines based on genogroup 1 virus have been used in Japan, and
Tetsuo Sato, Kazuki Oroku, Yoshiyuki Ohshima, Yoshiaki Furuya, Chihiro Sasakawa   +4 more
doaj   +1 more source