Results 1 to 10 of about 18,401 (261)

Discovery of Cetaben as a Novel Antiviral Agent Against Porcine Epidemic Diarrhea Virus From a Cholesterol-Lowering Compound Library. [PDF]

Transbound Emerg Dis
The devastating impact of porcine epidemic diarrhea virus (PEDV) on the global swine industry underscores an urgent need for effective antiviral therapies. Drug repurposing presents a promising strategy to accelerate the development of such treatments.
Li Y, Qin P, Zhang K, Ma N, Wang T, Chen Z, Yuan Y, Li D, Yu L, Li W, Du W, Li Y.   +11 more
europepmc   +2 more sources

Emergence of a Highly Virulent Porcine Epidemic Diarrhea Virus (PEDV) G2c Subtype in China: Isolation, Genetic and Pathogenic Characterization, and Cross-Neutralizing Antibody Response. [PDF]

Transbound Emerg Dis
Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus causing high mortality in neonatal piglets, continues to threaten global swine industries. Frequent mutations in the spike (S) protein of PEDV, particularly in emerging variants, have substantially compromised commercial vaccine efficacy.
Li YY, Fan CH, Li HX, Zhen HQ, Zhu YQ, Wang S, Wang B, Huang YW.   +7 more
europepmc   +2 more sources

How Does Porcine Epidemic Diarrhea Virus Escape Host Innate Immunity? [PDF]

Pathogens
Porcine epidemic diarrhea virus (PEDV), the causative agent of porcine epidemic diarrhea (PED), induces vomiting, watery diarrhea, and severe dehydration in pigs. It exhibits particularly high lethality in neonatal piglets, posing a significant threat to
Jinyuan Li, Hao Lu, Gaowei Hu, Shengmei Pang, Yuqing Xie, Guoqiang Zhu, Xueyan Ding   +6 more
doaj   +2 more sources

G2c-Lineage Dominance and S1 Epitope-Glycan Drift of Porcine Epidemic Diarrhea Virus in Guangdong Province, China, 2022–2024 [PDF]

Veterinary Sciences
Porcine epidemic diarrhea (PED), a severe and highly contagious disease induced by porcine epidemic diarrhea virus (PEDV), impacts pigs across all age groups but has a particularly high lethality in neonatal piglets, with mortality rates reaching 80 to ...
Liangzong Huang, Liming Yan, Mengyi Zeng, Jianhui Yao, Jiaqi Hu, Weilin Zhong, Lewen Su, Guangzhi Yan, Shengnan Chen, Yuhan Huang, Mingjie Liu   +10 more
doaj   +2 more sources

SHP-1 Promotes the Replication of Porcine Epidemic Diarrhea Virus by Inhibiting TRAF3-Mediated Type I Interferon Immune Responses [PDF]

Pathogens
Porcine epidemic diarrhea virus (PEDV), a member of the genus Alpha coronavirus, is one of the main pathogens causing piglet diarrhea. PEDV can enhance its replication by regulating host protein function.
Jiaqing Hu, Yuxin Kong, Yi Liu, Ning Li, Shijin Jiang   +4 more
doaj   +2 more sources

Immunoenhancing effects of Gynostemma Pentaphyllum Extract on mucosal immunity against porcine epidemic diarrhea virus. [PDF]

Front Vet Sci
Zhang Y, Tang R, Liu Y, Hao Z, Fan K, Xie S, Tang B, Wang S.   +7 more
europepmc   +3 more sources

Study on the antibody level differences of ped igg and iga, tge igg and por igg after immunization with different porcine viral diarrhea vaccine combinations [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
To prevent porcine viral diarrhea, a vaccine combination that can provide good antibody levels needs to be determined. In this study, we screened 30 pregnant sows divided into six experimental groups, namely, five immunized groups and one control group ...
Qiu-yong CHEN, Ru-jing CHEN, Xue-min WU, Yong-liang CHE, Bo HOU, Chen-yan WANG, Long-bai WANG, Lun-jiang ZHOU   +7 more
doaj   +1 more source

Correction: Immunoenhancing effects of Gynostemma Pentaphyllum Extract on mucosal immunity against porcine epidemic diarrhea virus. [PDF]

Front Vet Sci
Zhang Y, Tang R, Liu Y, Hao Z, Fan K, Xie S, Tang B, Wang S.   +7 more
europepmc   +3 more sources

The New Porcine Epidemic Diarrhea Virus Outbreak May Mean That Existing Commercial Vaccines Are Not Enough to Fully Protect Against the Epidemic Strains

Frontiers in Veterinary Science, 2021
Background: On October 30, 2020, piglets and sows in the farrowing house of a pig farm in Jiangxi showed clinical symptoms such as anorexia, watery diarrhea, and vomiting.
Qi Gao, Zezhong Zheng, Zezhong Zheng, Heng Wang, Heng Wang, Heng Wang, Songqiang Yi, Guihong Zhang, Guihong Zhang, Guihong Zhang, Guihong Zhang, Lang Gong, Lang Gong   +12 more
doaj   +1 more source

Modulation of Innate Antiviral Immune Response by Porcine Enteric Coronavirus

Frontiers in Microbiology, 2022
Host’s innate immunity is the front-line defense against viral infections, but some viruses have evolved multiple strategies for evasion of antiviral innate immunity.
Kunli Zhang, Kunli Zhang, Sen Lin, Jianhao Li, Shoulong Deng, Jianfeng Zhang, Jianfeng Zhang, Sutian Wang   +7 more
doaj   +1 more source