Results 71 to 80 of about 69,945 (257)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Metatranscriptomic assessment of diarrhoeic faeces reveals diverse RNA viruses in rotavirus group A infected piglets and calves from India

Frontiers in Cellular and Infection Microbiology, 2023
RNA viruses are a major group contributing to emerging infectious diseases and neonatal diarrhoea, causing morbidity and mortality in humans and animals.
Pradeep Sawant, Abhijeet Kulkarni, Rajkumar Mane, Renu Patil, Mallika Lavania   +4 more
doaj   +1 more source

Targeted-pig trial on safety and immunogenicity of serum-derived extracellular vesicles enriched fractions obtained from Porcine Respiratory and Reproductive virus infections [PDF]

, 2018
The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is the etiological agent of one of the most important swine diseases with a significant economic burden worldwide.
Borrás, Francesc E., del Portillo, Hernando A., Fraile Sauce, Lorenzo José, Montaner Tarbes, Sergio Roberto, Montoya, Maria, Novell, Elena, Tarancón, Vicens   +6 more
core   +4 more sources

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Emergence of Different Recombinant Porcine Reproductive and Respiratory Syndrome Viruses, China [PDF]

Scientific Reports, 2018
AbstractEpidemiological investigations were conducted on recently emerging porcine reproductive and respiratory syndrome virus (PRRSV) strains in Shandong province in 2014–2015. The proportion of the NADC30 strain identified by ORF7 sequence alignment has been gradually increasing.
Liu, Yanyan, Li, Jianda, Yang, Jie, Zeng, Hao, Guo, Lihui, Ren, Sufang, Sun, Wenbo, Chen, Zhi, Cong, Xiaoyan, Shi, Jianli, Chen, Lei, Du, Yijun, Li, Jun, Wang, Jinbao, Wu, Jiaqiang, Yu, Jiang   +15 more
openaire   +2 more sources

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Differences in virus receptor for type I and type II feline infectious peritonitis virus. [PDF]

, 1998
Feline infectious peritonitis viruses (FIPVs) are classified into type I and type II serogroups. Here, we report that feline aminopeptidase N (APN), a cell-surface metalloprotease on the intestinal, lung and kidney epithelial cells, is a receptor for ...
Hohdatsu, T, Izumiya, Y, Kida, K, Koyama, H, Yokoyama, Y   +4 more
core  

Lineage A betacoronavirus NS2 proteins and the homologous torovirus Berne pp1a carboxy-terminal domain are phosphodiesterases that antagonize activation of RNase L [PDF]

, 2017
Viruses in the family Coronaviridae, within the order Nidovirales, are etiologic agents of a range of human and animal diseases, including both mild and severe respiratory diseases in humans.
Chen, Annie I, Elliott, Ruth, Goldstein, Stephen A, Jha, Babal K, Li, Yize, Quiroz-Figueroa, Katherine, Silverman, Robert H, Thornbrough, Joshua M, Weiss, Susan R, Zhang, Rong   +9 more
core   +2 more sources

CD163 Expression Confers Susceptibility to Porcine Reproductive and Respiratory Syndrome Viruses [PDF]

Journal of Virology, 2007
ABSTRACT Direct functional screening of a cDNA expression library derived from primary porcine alveolar macrophages (PAM) revealed that CD163 is capable of conferring a porcine reproductive and respiratory syndrome virus (PRRSV)-permissive phenotype when introduced into nonpermissive cells.
Jay G, Calvert, David E, Slade, Shelly L, Shields, Rika, Jolie, Ramasamy M, Mannan, Robert G, Ankenbauer, Siao-Kun W, Welch   +6 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source