Results 91 to 100 of about 33,951 (255)

The Persistence-Inducing Toxin HokB Forms Dynamic Pores That Cause ATP Leakage

mBio, 2018
Bacterial populations harbor a small fraction of cells that display transient multidrug tolerance. These so-called persister cells are extremely difficult to eradicate and contribute to the recalcitrance of chronic infections.
Dorien Wilmaerts, Mariam Bayoumi, Liselot Dewachter, Wouter Knapen, Jacek T. Mika, Johan Hofkens, Peter Dedecker, Giovanni Maglia, Natalie Verstraeten, Jan Michiels   +9 more
doaj   +1 more source

Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane. [PDF]

Nat Commun, 2023
González-Magaña A, Tascón I, Altuna-Alvarez J, Queralt-Martín M, Colautti J, Velázquez C, Zabala M, Rojas-Palomino J, Cárdenas M, Alcaraz A, Whitney JC, Ubarretxena-Belandia I, Albesa-Jové D.   +12 more
europepmc   +1 more source

Pore-forming protein toxins: from structure to function

Progress in Biophysics and Molecular Biology, 2005
Pore-forming protein toxins (PFTs) are one of Nature's most potent biological weapons. An essential feature of their toxicity is the remarkable property that PFTs can exist either in a stable water-soluble state or as an integral membrane pore. In order to convert from the water-soluble to the membrane state, the toxin must undergo large conformational
Michael W, Parker, Susanne C, Feil
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

eIF2α confers cellular tolerance to S. aureus α-toxin

Frontiers in Immunology, 2015
We report on the role of conserved stress-response pathways for cellular tolerance to a pore formingtoxin. First, we observed that small molecular weight inhibitors including of eIF2α-phosphatase, jun-N-terminal kinase (JNK), and PI3-kinase sensitized ...
Gisela evon Hoven, Claudia eNeukirch, Sabine eFüser, Maria eBidna Petrivna, Martina eMeyenburg, Amable J. Rivas, Alexey eRyazanov, Randal J. Kaufman, Raffi V. Aroian, Matthias eHusmann   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tke5 is a Pseudomonas putida toxin that kills plant pathogens by depolarising membranes

Communications Biology
The soil bacterium Pseudomonas putida injects toxic proteins into neighbouring competitors, including resilient phytopathogens, using the Type VI secretion system (T6SS). The secretion of toxins endows P.
Carmen Velázquez, Alejandro Arce-Rodríguez, Jon Altuna-Alvarez, Jessica Rojas-Palomino, Andony Flores-Ceron, Citlaly Cando-Narvaez, Adrián Ruiz, Javier De la Peña Noya, Cristina Civantos, Amaia González-Magaña, María Queralt-Martín, Antonio Alcaraz, David Albesa-Jové, Patricia Bernal   +13 more
doaj   +1 more source

Is Proteolytic Cleavage Essential for the Enhanced Activity of Hydra Pore-Forming Toxin, HALT-4? [PDF]

Toxins (Basel), 2023
Yap WY, Hwang JS.
europepmc   +1 more source