Results 101 to 110 of about 1,369,932 (286)

Video_7_Molecular and Functional Analysis of Pore-Forming Toxin Monalysin From Entomopathogenic Bacterium Pseudomonas entomophila.MOV

, 2020
Pseudomonas entomophila is a highly pathogenic bacterium that infects insects. It is also used as a suitable model pathogen to analyze Drosophila's innate immunity. P.
Emil Salim (8627832), Aki Hori (8627835), Rangga Meidianto Asri (8627841), Takumi Nishiuchi (449337), Shoji Takeuchi (114102), Saori Nonaka (8627829), Noriyuki Kodera (107990), Koki Kamiya (605693), Ayu Masyita (8627844), Takayuki Kuraishi (8627847), Firzan Nainu (8627838)   +10 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

eLife, 2017
Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells. We have determined the 4.5 Å structure of the ~2.2 MDa pore complex of pneumolysin, the main virulence factor of Streptococcus pneumoniae, by cryoEM.
Katharina van Pee, Alexander Neuhaus, Edoardo D'Imprima, Deryck J Mills, Werner Kühlbrandt, Özkan Yildiz   +5 more
doaj   +1 more source

All in the family: the toxic activity of pore-forming colicins

Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target ...
van der Goot, F. G., Pattus, F., Lakey, J.H.   +2 more
core   +1 more source

Video_9_Molecular and Functional Analysis of Pore-Forming Toxin Monalysin From Entomopathogenic Bacterium Pseudomonas entomophila.MOV

, 2020
Pseudomonas entomophila is a highly pathogenic bacterium that infects insects. It is also used as a suitable model pathogen to analyze Drosophila's innate immunity. P.
Emil Salim (8627832), Aki Hori (8627835), Rangga Meidianto Asri (8627841), Takumi Nishiuchi (449337), Shoji Takeuchi (114102), Saori Nonaka (8627829), Noriyuki Kodera (107990), Koki Kamiya (605693), Ayu Masyita (8627844), Takayuki Kuraishi (8627847), Firzan Nainu (8627838)   +10 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Potentiation Effect Of 5FU by Fragaceatoxin C Pore-Forming Toxin in MCF-7 Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introduction: Chemotherapy has been restricted due to the high-dose side effects. In the present study, acceleration of the chemotherapeutic drug (5FU) entrance into MCF-7 cells has been explored by using a recombinant form of Fragaceatoxin C (FraC) pore-
Mohammad Hassan Kheirandish, Hossein Zarei Jaliani, Mehdi Imani   +2 more
doaj  

The Effect of Cholesterol on the Long-Range Network of Interactions Established among Sea Anemone Sticholysin II Residues at the Water-Membrane Interface

Marine Drugs, 2015
Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members.
Sara García-Linares, Ida Alm, Terhi Maula, José G. Gavilanes, Johan Peter Slotte, Álvaro Martínez-del-Pozo   +5 more
doaj   +1 more source

Replication Data for: Support Vector Machine-based Prediction of Pore-forming Toxins (PFT) using Distributed Representation of Reduced Alphabets

Curated dataset used for developing sequence-based SVM classifier for predicting pore-forming ...
Valadi K. Jayaraman, Hrushikesh Bhosale, Ramakrishnan, Vigneshwar   +2 more
core   +1 more source

Structure and function of bacterial pore-forming toxins [PDF]

, 2015
The pore-forming bacterial toxins are crutial virulence factors of pathogenic bacteria. Their essential feature is the capacity to form hydrophilic transmembrane pores in cytoplasmic membrane of target cells.
Suková, Anna
core