Results 221 to 230 of about 33,951 (255)

Staphylococcal Pore-Forming Toxins

2001
Together with Pseudomonas aeruginosa and Escherichia coli, Staphylococcus aureus (S. aureus) is the most frequently isolated bacteria in routine hospital testing. Like the two other pathogens, S. aureus may synthesize numerous virulence factors, develop multiple resistances to antibiotics, and be responsible for numerous no-socomial infections.
G, Prévost, L, Mourey, D A, Colin, G, Menestrina   +3 more
openaire   +2 more sources

Liposomes in the Study of Pore-Forming Toxins

2003
Publisher Summary Liposomes are the most practical and useful model system to study the effects of pore-forming toxins (PFTs) and similar agents. Compared with other systems, such as bilayer lipid membranes BLMs, they may not provide the same level of molecular detail about some specific aspects of the interaction but certainly have the advantage of ...
DALLA SERRA M, MENESTRINA G
openaire   +4 more sources

Staphylococcus aureus Pore-Forming Toxins

2016
Staphylococcus aureus (S. aureus) is a formidable foe equipped with an armamentarium of virulence factors to thwart host defenses and establish a successful infection. Among these virulence factors, S. aureus produces several potent secreted proteins that act as cytotoxins, predominant among them the beta-barrel pore-forming toxins.
Tamara, Reyes-Robles, Victor J, Torres
openaire   +2 more sources

Lysenin: A sphingomyelin specific pore-forming toxin

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
Sphingomyelin is a major sphingolipid in mammalian cells. Recent results indicate that sphingomyelin is a reservoir of lipid second messengers, ceramide and sphingosine-1-phosphate. Sphingomyelin is also a major component of sphingolipid and cholesterol-rich membrane domains (lipid rafts).
Hidehiko, Shogomori, Toshihide, Kobayashi   +1 more
openaire   +2 more sources

Serratia Type Pore Forming Toxins

Current Protein & Peptide Science, 2000
The Serratia marcescens hemolysin represents a new type of hemolysin and has been studied in great molecular detail with regard to structure, activation and secretion. It has nothing in common with the pore forming toxins of E. coli type (RTX toxins), the Staphylococcus aureus alpha-toxin or the thiol activated toxin of group A beta-hemolytic ...
openaire   +2 more sources

Cooperative Assembly of  -Barrel Pore-Forming Toxins

Journal of Biochemistry, 2004
Bacterial beta-barrel pore-forming toxins are secreted as water-soluble monomeric proteins and assemble into beta-barrel-shaped pores/channels through membranes of target cells, causing cell death and lysis. The pore assemblies that undergo various intermediate stages are symbolized by the association of multi-subunit structures in cells.
Vananh T, Nguyen, Yoshiyuki, Kamio
openaire   +2 more sources

Architecture of the pore forming toxin sticholysin I in membranes

Journal of Structural Biology, 2019
Sticholysin I (StI) is a toxin produced by the sea anemone Stichodactyla helianthus and belonging to the actinoporins family. Upon binding to sphingomyelin-containing membranes StI forms oligomeric pores, thereby leading to cell death. According to recent controversial experimental evidences, the pore architecture of actinoporins is a debated topic ...
Yadira P, Hervis, Aisel, Valle, Sabrina, Dunkel, Johann P, Klare, Liem, Canet, Maria E, Lanio, Carlos, Alvarez, Isabel F, Pazos, Heinz-J, Steinhoff   +8 more
openaire   +2 more sources

Pore-forming peptides and protein toxins

2003
PART 1 PORE-FORMING PROTEINS Staphylococcal Bicomponent Leucotoxins, Mechanisms of Action, Impact on Cells and Contribution to Virulence, Gilles Prevost, Gianfranco Menestrina, Didier A. Colin, Sandra Werner, Stephen Bronner, Mauro Dalla Serra, Lamin Baba Moussa, Manual Coraiola, Alain Gravet, and Henri Monteil The Formulation of Ion-permeable Channels
G Menestrina, M Dalla Serra, P Lazarovici   +2 more
openaire   +4 more sources

The Sensing of Membrane Microdomains Based on Pore-Forming Toxins

Current Medicinal Chemistry, 2013
Membrane rafts are transient and unstable membrane microdomains that are enriched in sphingolipids, cholesterol, and specific proteins. They are involved in intracellular trafficking, signal transduction, pathogen entry, and attachment of various ligands.
M, Skočaj, B, Bakrač, I, Križaj, P, Maček, G, Anderluh, K, Sepčić   +5 more
openaire   +2 more sources

The Family of Serratia Type Pore Forming Toxins

Current Protein & Peptide Science, 2005
The Serratia marcescens hemolysin represents the prototype of a growing family of pore forming toxins. The available bacterial genome sequences reveal Serratia hemolysin homologues in additional species. However, only S. marcescens hemolysin has been studied in great molecular detail.
openaire   +2 more sources