Results 1 to 10 of about 26,348 (114)

Bacillus thuringiensis as a factory producing parasporin toxins with promising anticancer properties: a review [PDF]

Microbial Cell Factories
Bacillus thuringiensis, a facultatively aerobic, endospore-forming Gram-positive bacterium, is widely distributed across diverse natural environments. This bacterium is recognized as a cell factory producing insecticidal Cry (crystalline) toxins, also ...
Natalia Musiuk, Wioleta Lewandowska, Aleksandra Rembiszewska, Izabela Święcicka   +3 more
doaj   +2 more sources

Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. [PDF]

Journal of Experimental Medicine, 1990
The cytotoxic activity and pore-forming protein (PFP) expression of human peripheral blood (PB) gamma/delta T cells were examined. Fresh gamma/delta T cells isolated from PB lymphocytes by fluorescence-activated cell sorting exhibited a substantial natural killer-like cytotoxic activity against K562 target cells and had a high cytotoxic potential ...
Mark Smyth, Okumura K, Yagita H
exaly   +3 more sources

Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules. [PDF]

Journal of Experimental Medicine, 1986
Histocompatibility-restricted cytotoxic T lymphocytes produce circular lesions on target cell membranes. The pore-forming protein (PFP or perforin 1) that forms these membrane lesions has been purified from lymphocytes. At 37 degrees C, in the presence of Ca2+, this protein polymerizes into a supramolecular tubular complex of Mr greater than 10(6) that
Podack E R, Cohn Z A
exaly   +3 more sources

Perforin and Granulysin-Mediated Cytotoxicity in Colorectal Cancer Patients [PDF]

Medicina
Background and Objectives: The incidence of colorectal cancer (CRC) in developed Western countries is constantly growing. CRC represents the third most common cancer and the second leading cancer-related cause of death worldwide.
Ludvig Letica, Ivana Šutić Lubina, Zdrinko Brekalo, Đordano Bačić, Jelena Roganović, Ana Đorđević, Ingrid Šutić Udović, Ivona Letica, Ivana Kotri, Ines Mrakovčić-Šutić   +9 more
doaj   +2 more sources

A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin

Frontiers in Immunology, 2021
Malaria remains one of the most serious health problems in developing countries. The causative agent of malaria, Plasmodium spp., have a complex life cycle involving multiple developmental stages as well as different morphological, biochemical and ...
Maria Andrea Hernández-Castañeda, Marilyne Lavergne, Pierina Casanova, Bryan Nydegger, Carla Merten, Bibin Yesodha Subramanian, Patricia Matthey, Nils Lannes, Pierre-Yves Mantel, Michael Walch   +9 more
doaj   +1 more source

Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites

Frontiers in Immunology, 2022
Gasdermins (GSDMs) are a group of proteins that are cleaved by inflammatory caspases to induce pore formation in the plasma membrane to cause membrane permeabilization and lytic cell death or pyroptosis.
Shanshan Wang, France Moreau, Kris Chadee   +2 more
doaj   +1 more source

A pore-forming protein implements VLR-activated complement cytotoxicity in lamprey [PDF]

Cell Discovery, 2017
AbstractLamprey is a basal vertebrate with a unique adaptive immune system, which uses variable lymphocyte receptors (VLRs) for antigen recognition. Our previous study has shown that lamprey possessed a distinctive complement pathway activated by VLR.
Wu, Fenfang, Feng, Bo, Ren, Yong, Wu, Di, Chen, Yue, Huang, Shengfeng, Chen, Shangwu, Xu, Anlong   +7 more
openaire   +2 more sources

Cytotoxic Activities of Leptospira interrogans Hemolysin SphH as a Pore-Forming Protein on Mammalian Cells [PDF]

Infection and Immunity, 2002
ABSTRACT Leptospirosis is a spirochetal zoonosis that causes an acute febrile systemic illness in humans. Leptospira sp. hemolysins have been shown to be virulence factors for the pathogenesis of leptospirosis. Previously, we cloned a hemolysin SphH of Leptospira interrogans serovar
Seoung Hoon, Lee, Sangduk, Kim, Seung Chul, Park, Min Ja, Kim   +3 more
openaire   +2 more sources

Characterization of a leukocidin identified in Staphylococcus pseudintermedius. [PDF]

PLoS ONE, 2018
Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F
Mohamed A Abouelkhair, David A Bemis, Richard J Giannone, Linda A Frank, Stephen A Kania   +4 more
doaj   +1 more source

Production and Functional Characterization of a Recombinant Predicted Pore-Forming Protein (TVSAPLIP12) of Trichomonas vaginalis in Nicotiana benthamiana Plants

Frontiers in Cellular and Infection Microbiology, 2020
Pore-forming proteins (PFPs) are a group of functionally versatile molecules distributed in all domains of life, and several microbial pathogens notably use members of this class of proteins as cytotoxic effectors.
Nicia Diaz, Chiara Lico, Cristina Capodicasa, Selene Baschieri, Daniele Dessì, Daniele Dessì, Eugenio Benvenuto, Pier Luigi Fiori, Pier Luigi Fiori, Paola Rappelli, Paola Rappelli   +10 more
doaj   +1 more source