Synthesized Geopolymers Adsorb Bacterial Proteins, Toxins, and Cells
Frontiers in Bioengineering and Biotechnology, 2020 Pore-forming and hemolytic toxins are bacterial cytotoxic proteins required for virulence in many pathogens, including staphylococci and streptococci, and are notably associated with clinical manifestations of disease.
John Popovich +10 more
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Novel Role for Animal Innate Immune Molecules: Enterotoxic Activity of a Snail Egg MACPF-Toxin
Frontiers in Immunology, 2020 Gastropod Molluscs rely exclusively on the innate immune system to protect from pathogens, defending their embryos through maternally transferred effectors. In this regard, Pomacea snail eggs, in addition to immune defenses, have evolved the perivitellin-
Matías L. Giglio +7 more
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Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens. [PDF]
PLoS ONE, 2014 Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations.
Jonatan Dorca-Arévalo +5 more
doaj +1 more source
Evaluating cytotoxic effects of recombinant fragaceatoxin C pore forming toxin against AML cell lines [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Current therapeutic strategies for cancer are associated with side effects and lack of specificity in treatments. Biological therapies including monoclonal antibodies and immune effectors have been the subject of multiple research projects.
Mahnaz Azadpour +6 more
doaj +1 more source
Noncytotoxic functions of killer cell granzymes in viral infections.
PLoS Pathogens, 2021 Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans.
Lisanne C de Jong +3 more
doaj +1 more source
The gasdermins: a pore-forming protein family expressed in the epidermis
Frontiers in Immunology, 2023 Gasdermins comprise a family of pore-forming proteins, which play critical roles in (auto)inflammatory diseases and cancer. They are expressed as self-inhibited precursor proteins consisting of an aminoterminal cytotoxic effector domain (NT-GSDM) and a ...
Marta Slaufova +5 more
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Cells, 2022 Claudins are a family of integral membrane proteins that enable epithelial cell/cell interactions by localizing to and driving the formation of tight junctions.
Chinemerem P. Ogbu +2 more
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Cytotoxic and apoptosis-inducing effects of wildtype and mutated Hydra actinoporin-like toxin 1 (HALT-1) on various cancer cell lines [PDF]
PeerJ, 2019 Background Hydra actinoporin like toxin -1 (HALT-1), is a small 18.5 kDa pore forming toxin derived from Hydra magnipapillata which has been shown to elicit strong haemolytic and cytolytic activity when in contact with cell membranes.
Teng Jia Ng +6 more
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A Novel Strategy for Enhance Potentiation of Meglumine antimoniate against Leishmania major In Vitro
Iranian Journal of Parasitology, 2019 Background: We aimed to design a different method of drug delivery for increased transfer of the choice drug (meglumine antimoniate) within the host cells.
Farzaneh MIRZAEI +4 more
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Perforins Expression by Cutaneous Gamma Delta T Cells
Frontiers in Immunology, 2020 Gamma delta (GD) T cells are an unconventional T cell type present in both the epidermis and the dermis of human skin. They are critical to regulating skin inflammation, wound healing, and anti-microbial defense.
Katelyn O'Neill +3 more
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