Results 21 to 30 of about 33,951 (255)
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins
Toxins, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Asier Etxaniz +3 more
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The Ionic Selectivity of Lysenin Channels in Open and Sub-Conducting States
Membranes, 2021 The electrochemical gradients established across cell membranes are paramount for the execution of biological functions. Besides ion channels, other transporters, such as exogenous pore-forming toxins, may present ionic selectivity upon reconstitution in
Andrew Bogard +6 more
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A biomimetic nanosponge that absorbs pore-forming toxins [PDF]
Nature Nanotechnology, 2013 Detoxification treatments such as toxin-targeted anti-virulence therapy offer ways to cleanse the body of virulence factors that are caused by bacterial infections, venomous injuries and biological weaponry. Because existing detoxification platforms such as antisera, monoclonal antibodies, small-molecule inhibitors and molecularly imprinted polymers ...
Hu, Che-Ming J. +4 more
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, 2001 Pore-forming bacterial protein toxins: an overview * The cholesterol-dependent cytolysins * Aerolysin from aeromonas hydrophyla and related toxins * Staphylococcal pore-forming toxins * RTX toxin structure and function, a story of numerous anomalies and few analogies in toxin biology * Helicobacter pylori vacuolating cytotoxin: cell intoxication and ...
Menestrina G, Dalla Serra M
+7 more sources
Inhibition of Pore-Forming Proteins
Toxins, 2019 Perforation of cellular membranes by pore-forming proteins can affect cell physiology, tissue integrity, or immune response. Since many pore-forming proteins are toxins or highly potent virulence factors, they represent an attractive target for the ...
Neža Omersa +2 more
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The Ins and Outs of Anthrax Toxin
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Sarah Friebe +2 more
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Pore Forming Protein Induced Biomembrane Reorganization and Dynamics: A Focused Review
Frontiers in Molecular Biosciences, 2021 Pore forming proteins are a broad class of pathogenic proteins secreted by organisms as virulence factors due to their ability to form pores on the target cell membrane.
Ilanila Ilangumaran Ponmalar +4 more
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Recent Insights into Clostridium perfringens Beta-Toxin
Toxins, 2015 Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect.
Masahiro Nagahama +5 more
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The MACPF/CDC family of pore-forming toxins [PDF]
Cellular Microbiology, 2008 Pore-forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey (e.g. venoms). This review focuses upon two families of globular protein PFTs: the cholesterol-dependent cytolysins (CDCs) and the membrane attack complex/perforin superfamily ...
Rosado, CJ +10 more
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Cellular and Molecular Life Sciences, 2002 Pore-forming toxins are widely distributed proteins which form lesions in biological membranes. In this review, bacterial pore-forming toxins are treated as a paradigm and discussed in terms of the structural principles on which they work. Then, a large family of bacterial toxins, the cholesterol-binding toxins, are analyzed in depth to provide an ...
openaire +3 more sources