Results 41 to 50 of about 1,369,932 (286)

The MACPF/CDC family of pore-forming toxins [PDF]

Cellular Microbiology, 2008
Pore-forming toxins (PFTs) are commonly associated with bacterial pathogenesis. In eukaryotes, however, PFTs operate in the immune system or are deployed for attacking prey (e.g. venoms). This review focuses upon two families of globular protein PFTs: the cholesterol-dependent cytolysins (CDCs) and the membrane attack complex/perforin superfamily ...
Rosado, CJ, Kondos, S, Bull, TE, Kuiper, MJ, Law, RHP, Buckle, AM, Voskoboinik, I, Bird, PI, Trapani, JA, Whisstock, JC, Dunstone, MA   +10 more
openaire   +3 more sources

Recent Insights into Clostridium perfringens Beta-Toxin

Toxins, 2015
Clostridium perfringens beta-toxin is a key mediator of necrotizing enterocolitis and enterotoxemia. It is a pore-forming toxin (PFT) that exerts cytotoxic effect.
Masahiro Nagahama, Sadayuki Ochi, Masataka Oda, Kazuaki Miyamoto, Masaya Takehara, Keiko Kobayashi   +5 more
doaj   +1 more source

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes. [PDF]

, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein.
Felix Schmidt, Armin Giese, Hans Kretzschmar, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Bötzel, Kai, Kai Bötzel, Johannes Levin, Schmidt, Felix, Frits Kamp, Giese, Armin, Kamp Frits, Kretzschmar Hans, Levin Johannes, Bötzel Kai, Schmidt Felix, Giese Armin   +17 more
core   +2 more sources

Role of Pore-Forming Toxins in Neonatal Sepsis [PDF]

Clinical and Developmental Immunology, 2013
Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci,Escherichia coli,Listeria monocytogenes, andStaphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease.
Andreas F.-P. Sonnen, Philipp Henneke
openaire   +4 more sources

Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin

Pathogens
Clostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo, Nan Yue, Ming Chen, Jiaxin Li, Ruomei Lv, Jing Wang, Tingting Liu, Jing Huang, Shan Gao, Yanwei Li, Bing Yuan, Jinglin Wang, Lin Kang, Bin Ji, Wenwen Xin   +14 more
doaj   +1 more source

Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process

Nature Communications, 2016
Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that ...
Ioan Iacovache, Sacha De Carlo, Nuria Cirauqui, Matteo Dal Peraro, F. Gisou van der Goot, Benoît Zuber   +5 more
doaj   +1 more source

Membrane deformation and layer-by-layer peeling of giant vesicles induced by the pore-forming toxin pneumolysin [PDF]

, 2019
Protein-membrane interactions that modify the shape of membranes are important for generating curvature, membrane deformation by protein-protein crowding or trafficking of vesicles. Giant vesicles represent a simplified but versatile model for biological
Drücker, Patrick, Babiychuk, Eduard B., Dittrich, Petra S., Draeger, Annette, Iacovache, Ioan, Zuber, Benoît, Bachler, Simon, Dittrich, Petra S.; id_orcid, Draeger A, Drücker P, Bachler S, Iacovache I, Zuber B, Babiychuk EB, Dittrich PS   +14 more
core   +2 more sources

Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line

Frontiers in Microbiology, 2021
Staphylococcus aureus (S. aureus) is well known to express a plethora of toxins of which the pore-forming hemolysin A (α-toxin) is the best-studied cytolysin.
David Krones, Marcel Rühling, Katrin Anne Becker, Tobias C. Kunz, Carolin Sehl, Kerstin Paprotka, Erich Gulbins, Erich Gulbins, Martin Fraunholz   +8 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source