Results 31 to 40 of about 33,951 (255)
Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process
Nature Communications, 2016 Aerolysin is a secreted bacterial pore forming toxin that inserts into the host plasma membrane, potentially leading to cell death. Here the authors present Cryo-EM structures of aerolysin arrested at different stages of the pore formation process that ...
Ioan Iacovache +5 more
doaj +1 more source
Role of Pore-Forming Toxins in Neonatal Sepsis [PDF]
Clinical and Developmental Immunology, 2013 Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci,Escherichia coli,Listeria monocytogenes, andStaphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease.
Andreas F.-P. Sonnen, Philipp Henneke
openaire +4 more sources
Purinergic Receptor Antagonists Inhibit Hemolysis Induced by Clostridium perfringens Alpha Toxin
PathogensClostridium perfringens alpha toxin (CPA), which causes yellow lamb disease in sheep and gas gangrene and food poisoning in humans, is produced by all types of C. perfringens and is the major virulence determinant of C. perfringens type A.
Zishuo Guo +14 more
doaj +1 more source
Host Glycan Recognition by a Pore Forming Toxin [PDF]
Structure, 2012 An exposed F-type lectin domain fused to the N-terminus of a cholesterol-dependent cytolysin scaffold allows Streptococcus mitis lectinolysin to cluster at fucose-rich sites on target cell membranes, thereby leading to increased pore-forming toxin activity.
Bouyain, Samuel, Geisbrecht, Brian V.
openaire +2 more sources
Frontiers in Microbiology, 2021 Staphylococcus aureus (S. aureus) is well known to express a plethora of toxins of which the pore-forming hemolysin A (α-toxin) is the best-studied cytolysin.
David Krones +8 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Oligomerization of Clostridium perfringens epsilon toxin is dependent upon caveolins 1 and 2. [PDF]
PLoS ONE, 2012 Evidence from multiple studies suggests that Clostridium perfringens ε-toxin is a pore-forming toxin, assembling into oligomeric complexes in the plasma membrane of sensitive cells. In a previous study, we used gene-trap mutagenesis to identify mammalian
Christine M Fennessey +3 more
doaj +1 more source
Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
Nature Communications, 2021 Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.
Uday Tak +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Despite 5‐year survival rates of over 90% among children and adolescents/young adults (CAYAs) with classic Hodgkin lymphoma (cHL), 15%–20% relapse after frontline therapy. Prior analysis of frontline Children's Oncology Group (COG) clinical trials demonstrated that, despite similar rates of relapse, non‐Hispanic Black (NHB) and ...
Mallorie B. Heneghan +14 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiation.
Alejandro J. Moyano +15 more
doaj +1 more source