Results 61 to 70 of about 1,369,932 (286)

Cytotoxic Effect of Recombinant Fragaceatoxin C on Peripheral Blood Mononuclear Cells [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objectives: Actinoporins from sea anemones are potent pore-forming toxins. Fragaceatoxin C belongs to this family with a molecular weight of 20 kDa that mainly binds sphingomyelin in membranes and forming 2nm in diameter cation-selective ...
Leyla Darbarfard, Mehdi Imani, Seyyed Meysam Abtahi Froushani   +2 more
doaj  

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

Cell Reports, 2020
Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu, Vitalij Cernysiov, Dominique Davidson, Hua Song, Jianlong Tang, Shanshan Luo, Yan Lu, Jin Qian, Ivayla E. Gyurova, Stephen N. Waggoner, Vincent Quoc-Huy Trinh, Romain Cayrol, Ayumu Sugiura, Heidi M. McBride, Jean-François Daudelin, Nathalie Labrecque, André Veillette   +16 more
doaj   +1 more source

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Resurfacing receptor binding domain of Colicin N to enhance its cytotoxic effect on human lung cancer cells

Computational and Structural Biotechnology Journal, 2021
Colicin N (ColN) is a bacteriocin secreted by Escherichia coli (E. coli) to kill other Gram-negative bacteria by forcefully generating ion channels in the inner membrane.
Wanatchaporn Arunmanee, Methawee Duangkaew, Pornchanok Taweecheep, Kanokpol Aphicho, Panuwat Lerdvorasap, Jesada Pitchayakorn, Chayada Intasuk, Runglada Jiraratmetacon, Armini Syamsidi, Pithi Chanvorachote, Chatchai Chaotham, Natapol Pornputtapong   +11 more
doaj   +1 more source

Horizontal black lipid bilayer membranes for studying pore-forming toxins

, 2018
The investigation of pore-forming proteins such as the toxin component C2IIa from the binaryClostridium botulinumtype C2 toxin is of particular interest for pharmaceutical applications,e.g., such as drug delivery into cells.
H. Barth, C. M. Frey, B. Mizaikoff, C. Kranz   +3 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Exolysin Shapes the Virulence of Pseudomonas aeruginosa Clonal Outliers

Toxins, 2017
Bacterial toxins are important weapons of toxicogenic pathogens. Depending on their origin, structure and targets, they show diverse mechanisms of action and effects on eukaryotic cells.
Emeline Reboud, Pauline Basso, Antoine P. Maillard, Philippe Huber, Ina Attrée   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Bacterial pore-forming toxins: The (w)hole story? [PDF]

Cellular and Molecular Life Sciences, 2007
Pore-forming toxins (PFTs) are the most common class of bacterial protein toxins and constitute important bacterial virulence factors. The mode of action of PFT is starting to be better understood. In contrast, little is known about the cellular response to this threat.
Gonzalez MR, Bischofberger M, Pernot L, van der Goot FG, Frêche B   +4 more
openaire   +3 more sources

Prevalence of Clostridium perfringens netE and netF toxin genes in the feces of dogs with acute hemorrhagic diarrhea syndrome

Journal of Veterinary Internal Medicine, 2019
Background Recently, novel pore‐forming toxin genes designated netE and netF were identified in a Clostridium perfringens type A strain isolated from a dog with acute hemorrhagic diarrhea.
Natalie Sindern, Jan S. Suchodolski, Christian M. Leutenegger, Iman Mehdizadeh Gohari, John F. Prescott, Anna‐Lena Proksch, Ralf S. Mueller, Kathrin Busch, Stefan Unterer   +8 more
doaj   +1 more source