Results 91 to 100 of about 816,043 (306)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Using Fractal Theory to Study the Influence of Movable Oil on the Pore Structure of Different Types of Shale: A Case Study of the Fengcheng Formation Shale in Well X of Mahu Sag, Junggar Basin, China

Fractal and Fractional
This study investigated the influence of movable oil on the pore structure of various shale types, analyzing 19 shale samples from Well X in the Mahu Sag of the Junggar Basin.
Hong Zhang, Zhengchen Zhang, Zhenlin Wang, Yamin Wang, Rui Yang, Tao Zhu, Feifei Luo, Kouqi Liu   +7 more
doaj   +1 more source

Nanoscale pore characteristics and fractal characteristics of organic-rich shale: An example from the lower Cambrian Niutitang Formation in the Fenggang block in northern Guizhou Province, South China

Energy Exploration & Exploitation, 2019
Organic-rich marine shale in South China has great potential for gas generation, and the pore structure has a considerable influence on the enrichment of shale gas. The nanoscale pore characteristics and fractal characteristics of the Niutitang shales in
Yang Gu, Wenlong Ding, Min Yin, Baocheng Jiao, Siyu Shi, Ang Li, Zikang Xiao, Zhitao Wang   +7 more
doaj   +1 more source

The Description of Shale Reservoir Pore Structure Based on Method of Moments Estimation.

PLoS ONE, 2016
Shale has been considered as good gas reservoir due to its abundant interior nanoscale pores. Thus, the study of the pore structure of shale is of great significance for the evaluation and development of shale oil and gas.
Wenjie Li, Changcheng Wang, Zejin Shi, Yi Wei, Huailai Zhou, Kun Deng   +5 more
doaj   +1 more source

Fractal characteristic of microscopic pore structure of tight sandstone reservoirs in Kalpintag Formation in Shuntuoguole area, Tarim Basin

Petroleum Research, 2020
Using the fractal geometry method, the microscopic pore structures of tight sandstone reservoirs in Kalpintag Formation of Shuntuoguole area in Tarim Basin were conducted fractal characterization on the base of test analysis data such as physical ...
Jun Peng, Haodong Han, Qingsong Xia, Bin Li   +3 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A comparative analysis of mercury intrusion and nitrogen adsorption methods for multifractal characterization of shale reservoirs in northern Songliao Basin

Scientific Reports
The northern Songliao Basin is shale-oil-rich with high exploration potential. However, its heterogeneity challenge reservoir characterization and evaluation, impeding exploration and development efforts.
Siyu Chen, Dameng Liu, Yingjin Wang, Weifeng Zhang, Qingwei Zheng, Xinran Yin   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pore structure characterization of porous building material by X-ray computed tomography (XCT) and X-ray microscopy (XRM)

e-Journal of Nondestructive Testing
 The pore structure of porous building materials, with pore elements ranging from nanometer to millimeter scale, often is a crucial factor that impacts the material’s functional properties.
Chengnan Shi, Jeroen Soete, Hans Janssen
doaj   +1 more source