Results 41 to 50 of about 421,042 (302)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Artificial Neural Network Modeling for Spatial and Temporal Variations of Pore-Water Pressure Responses to Rainfall

Advances in Meteorology, 2015
Knowledge of spatial and temporal variations of soil pore-water pressure in a slope is vital in hydrogeological and hillslope related processes (i.e., slope failure, slope stability analysis, etc.).
M. R. Mustafa, R. B. Rezaur, H. Rahardjo, M. H. Isa, A. Arif   +4 more
doaj   +1 more source

Examining the Effect of Pore Size Distribution and Shape on Flow through Unsaturated Peat using Computer Tomography [PDF]

, 2009
The hydraulic conductivity of unsaturated peat soil is controlled by the air-filled porosity, pore size and geometric distribution as well as other physical properties of peat materials. This study investigates how the size and shape of pores affects the
Elliot, T.R., Elrick, David, Heck, Richard J., Price, Jonathan S., Quinton, William L., Rezanezhad, Fereidoun   +5 more
core   +2 more sources

Water and Methane in Shale Rocks: Flow Pattern Effects on Fluid Transport and Pore Structure [PDF]

, 2015
Using molecular dynamics simulations we study the two-phase flow of water and methane through slit-shaped nano-pores carved from muscovite. The simulations are designed to investigate the effect of flow patterns on the fluids transport and on the pore ...
Ahmadlouydarab, Ahmadlouydarab, Berendsen, Blatt, Bruus, Cipolla, Cygan, Freund, Gong, Ho, Ho, Hughes, Indraratna, Joekar-Niasar, Kannam, Lauga, Martin, Muskat, Nara, Niessner, Pevear, Qiao, Ranjith, Rao, Rebrov, Roydhouse, Shao, Silin, Tambach, Tanikawa, Tanikawa, Teich-McGoldrick, Teich-McGoldrick, Thomas, Tian, Toton, Travis, Wang, Wang, White, Wu, Wu, Yethiraj, Zhu   +43 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Numerical analysis of seepage–deformation in unsaturated soils [PDF]

, 2014
A coupled elastic–plastic finite element analysis based on simplified consolidation theory for unsaturated soils is used to investigate the coupling processes of water infiltration and deformation.
A Qin, AW Bishop, DG Fredlund, DV Griffiths, E Conte, E Garcia, EE Alonso, EL Liu, Enlong Liu, F Cai, F Stauffer, G Deng, Gang Deng, H Rahardjo, H Yang, H Yang, HA Basha, HA Basha, Hai-Sui Yu, HJ Morel-Seytoux, HJ Morel-Seytoux, Jianhai Zhang, JM Chen, LT Zhan, LZ Wu, MM Nezhad, N Khalili, RI Borja, RI Borja, RI Borja, RJ Bathurst, RW Lewis, SE Cho, SE Serrano, Siming He, TMH Le, W Ehlers, W Sun, X Song, ZJ Shen   +39 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modelling the influence of pore size on the response of materials to infrared lasers – an application to human enamel [PDF]

, 2005
We present an analytical model for a ceramic material (hydroxyapatite) containing nanometre-scale water pores, and use it to estimate the pressure at the pore as a function of temperature at the end of a single 0.35 µs laser pulse by Er:YAG (2.94 µm) and
Ramos, Marta M. D., Vila Verde, A.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source