Results 91 to 100 of about 19,532 (189)

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin   +14 more
wiley   +1 more source

Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis

open access: yeseFood, Volume 7, Issue 3, June 2026.
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng   +5 more
wiley   +1 more source

Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao   +4 more
wiley   +1 more source

Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis

open access: yesMaterials Today Bio
Acute pancreatitis (AP) is a highly fatal pancreatic inflammation. In recent years, synthetic nanoparticles have been extensively developed as drug carriers to address the challenges of systemic adverse reactions and lack of specificity in drug delivery.
Fengyu Shi   +16 more
doaj   +1 more source

Protein Tyrosine Phosphatase 1B‐Mediated Granulosa Cell Insulin Resistance Links Metabolic Stress to Aging‐Relevant Ovarian Dysfunction and Is Reversed by Gengnianchun

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Metabolic stress induces insulin resistance and upregulates PTP1B in granulosa cells, leading to aging‐relevant ovarian dysfunction. Gengnianchun (GNC) suppresses PTP1B, restores IRS1–AKT2–GLUT4 signaling, and preserves follicles, highlighting PTP1B as a therapeutic target for ovarian dysfunction in metabolically vulnerable states.
Yanqiu Rao   +6 more
wiley   +1 more source

A New Triterpenoid from Traditional Chinese Medicine Poria Cocos

open access: yes, 2010
A new triterpenoid, 3,4-secolanosta-4(28),7,9,24Z-tetraen-3,26-dioic acid, along with two known compounds 16-deoxyporicoic acid B and 3-epidehydrotrametenolic acid were isolated from the dried sclerotia of Poria cocos Wolf (Polyporaceae). The structures
Bei Qin   +4 more
core   +1 more source

Study on extraction and antibacterial effect of polysaccharides from Poria cocos mushroom skin

open access: yesSiliao yanjiu
The experiment aimed to study the extraction process and antibacterial effect from Poria cocos mushroom skin. Using Poria cocos mushroom skin as raw material, polysaccharides were extracted by dilute alkali extraction method.
WANG Li, XIN Yupeng, BAI Jian
doaj  

Multi-omics-guided discovery of CYP5035 enables heterologous production and engineering of pachymic acid in yeast

open access: yesJournal of Biological Engineering
Pachymic acid is a key bioactive triterpenoid of Poria cocos, a medicinal fungus widely used in traditional Chinese medicine, and is responsible for its anti-tumor and anti-inflammatory activities.
Ceyuan Liu   +6 more
doaj   +1 more source

A new epidioxy-tetracyclic triterpenoid from Poria cocos Wolf

open access: yes, 2016
A new epidioxy-tetracyclic triterpenoid, 3-(2-hydroxyacetoxy)-5α, 8α-peroxydehydrotumulosic acid (10), along with nine known compounds were isolated from Poria cocos Wolf (Polyporaceae).
Shiping Li (1390375)   +6 more
core   +1 more source

Research progress on structural characterization and bioactivities of Poria cocos and Ganoderma polysaccharides

open access: yesFood & Medicine Homology
Poria cocos, Ganoderma lucidum, and Ganoderma sinense, as the famous medicine and food homologous fungal, has been used as traditional Chinese medicine for a long history. Polysaccharide is one of the most important bioactive ingredients of P.
Yi-Kun Xie   +4 more
doaj   +1 more source

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