Results 81 to 90 of about 6,033 (210)

ShenQi DiHuang Decoction (SQDHD) Ameliorates Neuroinflammation and Neuropsychiatric Manifestations in Pristane Induced Lupus Mice via Blocking JAK1‐STAT3 Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
SQDHD exerts neuroprotective effects and alleviates behavioral deficits in PIL mice, likely by inhibiting the JAK1‐STAT3 pathway in activated CVECs. These findings underscore the therapeutic potential of SQDHD and establish it as a promising candidate for the treatment of NPSLE.
Jie Chen, Chumiao Cui, Fei Xu, Jiayan Feng, Jingyu Chen, Xueru Wang, Hui Yuan, Chenye Jin, Yutian Li, Yang Yun   +9 more
wiley   +1 more source

Non‐Starch Purple Sweet Potato Polysaccharide Ameliorates Lipopolysaccharides‐Induced Acute Colitis by Regulating Gut Function and Inactivating the NOD‐Like Receptor Protein 3 Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Purple sweet potato polysaccharide (PSP) ameliorates lipopolysaccharide‐induced ulcerative colitis in mice through multiple coordinated mechanisms. Oral PSP administration dose‐dependently: (1) Modulates gut microbiota composition and increases short‐chain fatty acid levels; (2) strengthens intestinal barrier function; (3) attenuates systemic ...
Peng Yu, Jitao Ling, Yixuan Chen, Panpan Xia, Yuting Wu, Jianqi Liang, Xuehong Zheng, Yunkun Liu, Zhou Xu, Yiming Gan, Ao Shi, Wenting Wang, Xiao Liu, Yaqi Rong, Yan Xiong, Jianping Liu, Xiaoping Yin, Jing Zhang, Deju Zhang   +18 more
wiley   +1 more source

Tissue invasion and metastasis: molecular, biological and clinical perspectives [PDF]

, 2015
Cancer is a key health issue across the world, causing substantial patient morbidity and mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to distant sites, with metastatic diseases accounting for a vast ...
Amedei, A., Amin, A., Ashraf, S., Dhawan, P., et al., Fujii, H., Georgakilas, A., Gieseler, F., Honoki, K., Jiang, W., Katoh, M., Niccolai, E., Prince, M., Sanders, A., Sarkar, M., Sliva, D., Spano, D., Subbarayan, P., Thompson, S., Ungefroren, H., Zollo, M.   +20 more
core   +1 more source

Jianpi Jiedu Xiaozheng Fang Regulates Hepatocellular Carcinoma Proliferation and Metastasis Based on Network Pharmacology

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Hepatocellular carcinoma (HCC) is a primary malignant tumour that impacts patients' quality of life. Currently, clinical experience from The First Affiliated Hospital of Guangzhou University of Chinese Medicine suggests that Jianpi Jiedu Xiaozheng Fang (JPJDXZF) demonstrates promising efficacy in the treatment of HCC.
Bin Li, Han‐Qian Shi, Rui Luo, Zi‐Qi Zhang, Xiao‐Chen Dong, Xiao‐Hua Li, Shi‐Qin Ye, Chong Zhong   +7 more
wiley   +1 more source

Pachymic Acid Targets PI3K/Akt Signaling Pathway to Attenuate tPA‐Induced Hemorrhagic Transformation After Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Pachymic acid protects blood–brain barrier (BBB) integrity by decreasing the degradation of tight junction proteins caused by tissue plasminogen activator (tPA). Pachymic acid activates the PI3K/Akt pathway via direct binding to PI3K protein, mitigating BBB damage and hemorrhagic transformation induced by tPA after ischemic stroke.
Yongshi Wu, Tong Zhang, Ruoqi Li, Yige Wu, Congmin Wei, Fangming Sun, Shanshan Zhang, Xiang Fan   +7 more
wiley   +1 more source

Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis

Materials Today Bio
Acute pancreatitis (AP) is a highly fatal pancreatic inflammation. In recent years, synthetic nanoparticles have been extensively developed as drug carriers to address the challenges of systemic adverse reactions and lack of specificity in drug delivery.
Fengyu Shi, Akmal Ergashev, Zhenyan Pan, Hongwei Sun, Lingming Kong, Yuepeng Jin, Tan Zhang, Zhu Liu, Haonan Xie, Jinhui Wang, Huiping Li, Yi Wang, Lifei Zheng, Jianliang Shen, Andreas Herrmann, Gang Chen, Hongru Kong   +16 more
doaj   +1 more source

Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1/KISS1R signaling [PDF]

, 2015
Renal cell carcinoma (RCC) is a common urological cancer worldwide and is known to have a high risk of metastasis, which is considered responsible for more than 90% of cancer associated deaths. Honokiol is a small-molecule biphenol isolated from Magnolia
Castillo, Victor, Cheng, Shujie, Eliaz, Isaac, Sliva, Daniel   +3 more
core   +2 more sources

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source

Copper translocation from preserved wood exposed to wood decay fungi [PDF]

, 2002
Copper tolerance by wood decay fungi is one of the most important problems in the field of wood preservation. These fungi are potential danger for preserved wood in use, wood with expected lifetime of 30 years.
Amartey, Sam, Humar, Miha, Pohleven, Franc   +2 more
core  

Pinellia pedatisecta Schott‐Derived Exosome‐Like Nanovesicles Promote Apoptosis in Colorectal Cancer by Regulating the Lysosome‐Mediated Mitophagy Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Pinellia pedatisecta Schott‐derived exosome‐like nanovesicles (PPS‐ELNs) are efficiently taken up by colorectal cancer (CRC) cells and exhibit tumor‐targeting properties. Mechanistically, PPS‐ELNs suppress tumor progression by inhibiting the proliferation of CRC cells and promoting apoptosis through regulation of the lysosome‐mediated mitophagy pathway.
Pingsheng Zhou, Qingling Zhang, Xiaotao Zhou, Ge Zhang, Shiping Cheng   +4 more
wiley   +1 more source