Results 71 to 80 of about 135,655 (317)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sharp global nonlinear stability for a fluid overlying a highly porous material

, 2009
The stability of convection in a two-layer system in which a layer of fluid with a temperature-dependent viscosity overlies and saturates a highly porous material is studied. Owing to the difficulties associated with incorporating the nonlinear advection
A. A. Hill, Hill, Antony A., Carr, Magda, M. Carr   +3 more
core   +1 more source

Microfluidic systems for the analysis of the viscoelastic fluid flow phenomena in porous media [PDF]

, 2011
In this study, two microfluidic devices are proposed as simplified 1-D microfluidic analogues of a porous medium. The objectives are twofold: firstly to assess the usefulness of the microchannels to mimic the porous medium in a controlled and simplified ...
P. J. Hamersma, Pinho, F.T. (author), Galindo-Rosales, Francisco J, Oliveira, M.S.N., E. van Bokhorst, Hamersma, P.J., Campo-Deaño, L., Fernando T. Pinho, F. T. Pinho, Francisco J. Galindo Rosales, Laura Campo Deaño, Hamersma, P.J. (author), Galindo-Rosales, F.J., Manuel A. Alves, Campo-Deaño, Laura, M. A. Alves, Oliveira, M. S. N., L. Campo-Deaño, Galindo-Rosales, F. J., M. S. N. Oliveira, Alves, M.A. (author), Mónica S. N. Oliveira, Oliveira, M.S.N. (author), F. J. Galindo-Rosales, Oliveira, Monica, Alves, M.A., Van Bokhorst, E. (author), Campo-Deano, L. (author), Pinho, F.T., van Bokhorst, E., Galindo-Rosales, F.J. (author)   +30 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Nonlinear stability of the one-domain approach to modelling convection in superposed fluid and porous layers

, 2010
Studies of the nonlinear stability of fluid/porous systems have been developed very recently. A two-domain modelling approach has been adopted in previous works, but was restricted to specific configurations.
Carr, Magda, Hill, A A
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Mixed and galerkin finite element approximation of flow in a linear viscoelastic porous medium

, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2013 ElsevierThis article has been made available through the Brunel Open Access Publishing Fund.We propose two fully discrete
Shaw, Simon, Wheeler, Mary F., Rohan, E, Whiteman, JR, Rohan, Eduard, Whiteman, John R., Shaw, S, Wheeler, MF   +7 more
core   +1 more source

Performance of the solar air vortex engine using a porous medium: an experimental assessment

Results in Engineering
This study investigates the performance of a solar air vortex engine using a porous medium for thermal energy storage. This is one of the first experimental studies evaluating porous media (Black-coated glass) for thermal storage in solar vortex engines.
Marwan A. Ali, Omer K. Ahmed
doaj   +1 more source

ROTARY VIBRATIONS OF A POROUS SPHERICAL SHELL WITH AN IMPERMEABLE CORE IN A VISCOUS LIQUID

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. The investigation of the viscous liquid flows in contact with the oscillating submerged porous bodies of various configurations is of a considerable interest for hydrodynamics in the connection with a great theoretical importance and ...
O. A. Bazarkina, N. G. Taktarov
doaj   +1 more source