Results 81 to 90 of about 2,358,015 (296)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Performance of the solar air vortex engine using a porous medium: an experimental assessment

Results in Engineering
This study investigates the performance of a solar air vortex engine using a porous medium for thermal energy storage. This is one of the first experimental studies evaluating porous media (Black-coated glass) for thermal storage in solar vortex engines.
Marwan A. Ali, Omer K. Ahmed
doaj   +1 more source

ROTARY VIBRATIONS OF A POROUS SPHERICAL SHELL WITH AN IMPERMEABLE CORE IN A VISCOUS LIQUID

Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. The investigation of the viscous liquid flows in contact with the oscillating submerged porous bodies of various configurations is of a considerable interest for hydrodynamics in the connection with a great theoretical importance and ...
O. A. Bazarkina, N. G. Taktarov
doaj   +1 more source

Pressures Inside a Nano-Porous Medium. The Case of a Single Phase Fluid

Frontiers in Physics, 2019
We define the pressure of a porous medium in terms of the grand potential and compute its value in a nano-confined or nano-porous medium, meaning a medium where thermodynamic equations need be adjusted for smallness.
Olav Galteland, Dick Bedeaux, Bjørn Hafskjold, Signe Kjelstrup   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Experimental study on effects of volume fraction difference and porous media on bidirectional propagation of methane explosion

Meikuang Anquan
To investigate the bidirectional propagation law and inhibition effect of gas explosions, experimental studies were conducted on a self-built explosion pipeline platform.
Chang Lu, Wei Wang, Bei Pei, Di Wang, Shiwei Li, Jian Wang   +5 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

On the signed porous medium flow

Networks and Heterogeneous Media, 2012
We prove that the signed porous medium equation can be regarded as limit of an optimal transport variational scheme, therefore extending the classical result for positive solutions of [13] and showing that an optimal transport approach is suited even for treating signed densities.
openaire   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source