Results 51 to 60 of about 31,642 (216)

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Acute Intermittent Porphyria: Current Perspectives And Case Presentation

Therapeutics and Clinical Risk Management, 2019
Acute intermittent porphyria (AIP) is an autosomal dominant metabolic disorder characterized by a deficiency in heme biosynthesis. Heme biosynthesis occurs throughout the body, but it is most prominent in the erythroblastic system and liver.
Zachary P. Spiritos, Shakirat Salvador, Diana M. Mosquera, Julius M. Wilder   +3 more
semanticscholar   +1 more source

Porphyria: a case report

Journal of Medical Case Reports, 2022
Background Prompt diagnosis of metabolic disorders in a resource-limited country like Nepal is daunting. Acute intermittent porphyria is a rare but common hepatic porphyria mostly seen in females of the reproductive age group.
Sujata Baidya, Pratibha Kandel, Smrity Rajkarnikar, Anuradha Kadel, Apeksha Niraula, Raju Kumar Dubey, Machhindra Lamichhane, Mithileshwer Raut, Aseem Bhattarai, Eans Tara Tuladhar, Vijay Kumar Sharma   +10 more
doaj   +1 more source

Afamelanotide Is Associated with Dose-Dependent Protective Effect from Liver Damage Related to Erythropoietic Protoporphyria

Life, 2023
In animal models, melanocyte-stimulating hormones (MSHs) protect the liver from various injuries. Erythropoietic protoporphyria (EPP), a metabolic disorder, leads to the accumulation of protoporphyrin (PPIX).
Anna-Elisabeth Minder, Xiaoye Schneider-Yin, Henryk Zulewski, Christoph E. Minder, Elisabeth I. Minder   +4 more
doaj   +1 more source

Therapeutic Monitoring of Patients With Hereditary Tyrosinemia Type 1—A Belgian Monocentric Experience

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Hereditary tyrosinemia type I (HT‐1) is a rare metabolic disorder treated by NTBC, requiring careful therapeutic and nutritional monitoring. While follow‐up traditionally relies on urinary succinylacetone, plasma NTBC and plasma amino acids, dried blood spot (DBS) methods have introduced alternative monitoring options.
Anne‐Sophie Adam, Lionel Marcélis, David Fage, Elise Mathieu, Aurélie Empain, Céline Dufour, Frédéric Cotton, Corinne de Laet   +7 more
wiley   +1 more source

New pharmacotherapies for the erythropoietic protoporphyrias: an analysis of trial protocols from a patient perspective

Orphanet Journal of Rare Diseases
Background The erythropoietic protoporphyrias (EPP) are a group of ultra-rare (1:100.000) inborn errors of the heme biosynthesis characterised by painful phototoxic reactions in tissue exposed to visible light.
Cornelia Dechant, Sebastian Wäscher, Francesca Granata, Nicole Gusset, Mårten Pettersson, Mehmet Hakan Aksözen, Marc Höglinger, Rocco Falchetto, Jasmin Barman-Aksözen   +8 more
doaj   +1 more source

Practical Recommendations in the Treatment of Acute and Chronic Life-Threatening Infectious Diseases in Patients with Acute Hepatic Porphyria

Metabolites
Background: Acute hepatic porphyrias (AHPs) represent inherited metabolic disorders of the heme biosynthesis pathway, leading to neurological and systemic impairment. Despite the presence of well-recognized chronic symptoms and signs, acute neurological,
Bruno de Mattos Lombardi Badia, Paulo de Lima Serrano, João Paulo Barile, Daniel Delgado Seneor, Patrícia Marques Mendes, Renan Brandão Rambaldi Cavalheiro, Kaliny Oliveira Peixoto, Igor Braga Farias, Roberta Ismael Lacerda Machado, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bulle Oliveira, Paulo Sgobbi   +11 more
doaj   +1 more source

Sun Protection Advice for the South African Population for the Prevention and Management of Skin Diseases

International Journal of Dermatology, Volume 65, Issue 1, Page 57-68, January 2026.
ABSTRACT Sun protection is critical for the prevention and management of skin cancer and other photosensitive dermatoses in South Africa's diverse population. This review expands on previously published sun protection advice for skin cancer prevention by providing tailored advice for individuals with specific dermatological conditions.
Thuraya Isaacs, Tarryn Jacobs, Dagmar Whitaker, Willem Visser, Kim Wiid, Ncoza C. Dlova, Caradee Y. Wright, Bianca Tod   +7 more
wiley   +1 more source

5‐Aminolevulinic Acid–Based Photodynamic Therapy (ALA‐PDT) for Bowen’s Disease in Chinese Patients: A Multicenter Prospective Study

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background In China, the common treatment for Bowen’s disease (BD) is surgical excision. Although 5‐aminolevulinic acid–based photodynamic therapy (ALA‐PDT) has proven effective for BD in Caucasian patients, there is limited research on its effectiveness in Asian patients.
Menglong Ran, Yang Tang, Wenyu Wu, Miaojian Wan, Liang Zhang, Jianglin Zhang, Siliang Xue, Hang Li, Yun-Sheng Liang   +8 more
wiley   +1 more source

Drug-associated porphyria: a pharmacovigilance study

Orphanet Journal of Rare Diseases
Background The potentially fatal attacks experienced by porphyria carriers are triggered by various porphyrinogenic drugs. However, determining the safety of particular drugs is challenging. Methods We retrospectively used the U.S.
Qi Wang, Jun ling Zhuang, Bing Han, Miao Chen, Bin Zhao   +4 more
doaj   +1 more source