Results 91 to 100 of about 87,831 (289)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Synthesis of Novel Chlorins and Carotenoid-Porphyrin Dyads

, 2010
The first part of this thesis discusses the synthesis of chlorins bearing electron donating groups in the 3-position. A 3-dimethylaminochlorin ZnC-(NMe2)3M10 was synthesized in 49% yield, a 3-methoxychlorin ZnC-OMe3M10 was synthesized in 19% yield, and ...
Gauger, Kelly Ann
core  

Porphyrin-Implanted Carbon Nanodots for Photoacoustic Imaging and in Vivo Breast Cancer Ablation

, 2018
The incorporation of intensive light absorbing porphyrins macrocycles with biocompatible nanoparticles would lead to new nanomaterials with multiple imaging and therapeutic modalities.
Fengshou Wu (842536), Yuchen Cai (5374148), Huifang Su (3912466), Wenqi Jiang (1638793), Wai-Kwok Wong (842538), Xunjin Zhu (842539)   +5 more
core   +1 more source

Origin of the Distinctive Electronic Structure of Co- and Fe-Porphyrin-Nitrene and Its Effect on Their Nitrene Transfer Reactivity

, 2023
Metal-bound nitrene species are the crucial intermediate in catalytic nitrene transfer reactions exhibited by engineered enzymes and molecular catalysts.
Bhaskar Mondal (1298439), Mayank Mahajan (10743447)   +1 more
core   +1 more source

Greener Solvents for the Photoisomerization and Catalytic Heat Release of a Norbornadiene‐Based Molecular Solar Thermal Energy Storage System

Advanced Science, EarlyView.
A Molecular Solar Thermal (MOST) system combining a scalable norbornadiene–quadricyclane photoswitch, a biodegradable solvent, propylene carbonate, and noble and first‐row metal catalysts, is presented. Propylene carbonate boosts photoisomerization quantum yield by 25% compared to toluene, prolongs energy storage by an additional 15 days, and enables ...
Lucien Magson, Helen Hölzel, Rebecca J. Salthouse, Liang Fei, Pedro Ferreira, Vitor A. S. Almodovar, Kasper Moth‐Poulsen, Ignacio Funes‐Ardoiz, Diego Sampedro   +8 more
wiley   +1 more source

Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation

Angewandte Chemie, EarlyView.
The iron(III)‐peroxo complex [FeIII(O2)(12‐TMC)]+ exhibits bifurcating pathways in indole oxidation. N─H indoles undergo N─H H‐atom abstraction, supported by a KIE of 5.2 for N─H/N–D 2,3‐dimethylindoles, whereas N‐methylindoles react via electrophilic addition of the iron‐peroxo group to the C2–C3 double bond of the indole ring, forming iron ...
Wenjuan Zhu, Peng Wu, Binju Wang, Kallol Ray, Wonwoo Nam   +4 more
wiley   +2 more sources

Porphyrin-based MOFs for sensing environmental pollutants

Utilizing porphyrin molecules as the building blocks (ligands) of metal–organic frameworks (MOFs) leads to porphyrinic MOFs (including incorporation of functional materials into porphyrinic MOFs), whereas the immobilization of porphyrin molecules into ...
Weijin Li (2997675), Rong Cao (498367), Roland A. Fischer (15446514), Mian Zahid Hussain (5676575), Song Ye (477701), Xusheng Wang (11793562), Pan Gao (380188), Soumya Mukherjee (14069103), Martin Elsner (9543811)   +8 more
core   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Second‐Sphere Aromatic Substitutions That Tune H‐Atom Transfer Reactivity Observed for a Series of S = 1 Nonheme FeIV=O Complexes: An Enthalpy‐Entropy Compensation Effect

Angewandte Chemie, EarlyView.
A series of oxoiron(IV) complexes was synthesized to determine the impact of electronically tuned aromatic substitution in the secondary sphere of the ligand. Despite possessing identical electronic properties, they show significant differences in C─H oxidation reactions.
Abhishek Das, Jin Xiong, Victor G. Young Jr., Yisong Guo, Marcel Swart, Lawrence Que Jr.   +5 more
wiley   +2 more sources

Inverted porphyrins and expanded porphyrins: An overview

Journal of Chemical Sciences, 2002
Porphyrins and metallopophyrins have attracted the attention of chemists for the past 100 years or more owing to their widespread involvement in biology. More recently, synthetic porphyrins and porphyrin-like macrocycles have attracted the attention of researchers due to their diverse applications as sensitizers for photodynamic therapy, MRI ...
S. K. Pushpan, S. Venkatraman, V. G. Anand, J. Sankar, H. Rath, T. K. Chandrashekar   +5 more
openaire   +2 more sources