Results 21 to 30 of about 56,408 (287)

Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils

Gut microbes, 2022
Intratumor microbiome shapes the immune system and influences the outcome of various tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is highly epidemically connected with pancreatic cancer (PC). However, its causative
Qin Tan, Xiao Ma, Bing-Hu Yang, Ye Liu, Yibin Xie, Xijun Wang, W. Yuan, Jie Ma   +7 more
semanticscholar   +1 more source

Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases

Pathogens, 2022
Porphyromonas gingivalis is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria.
Lorena Horvat Aleksijević, Marko Aleksijević, I. Škrlec, Marko Šram, M. Šram, J. Talapko   +5 more
semanticscholar   +1 more source

Macrophage Subset Sensitivity to Endotoxin Tolerisation by Porphyromonas gingivalis [PDF]

, 2013
Macrophages (MΦs) determine oral mucosal responses; mediating tolerance to commensal microbes and food whilst maintaining the capacity to activate immune defences to pathogens.
AD Foey, Andrew D. Foey, B Pulendran, C Porta, CW Cutler, E Gemmell, FO Martinez, FR Greten, GD Tribble, GP Garlet, H Okada, HE Barksby, HJ Robertshaw, HM Wilson, J Fletcher, L Duncan, LA Ximenez-Fyvie, LAJ O'Neill, LE Smythies, M Daigneault, M Hirschfeld, M Muthukuru, MA Dobrovolskaia, O Yilmaz, O Yilmaz, P Ezzo, PC Heinrich, PD Smith, R Jotwani, R Merry, RP Darveau, S Sato, SK Biswas, SL Foster, SS Socransky, StJohn Crean, T Hagemann, T Tervonen, Y Liu, YG Kim, Z Xing, Özlem Yilmaz   +41 more
core   +8 more sources

The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

Frontiers in Cellular and Infection Microbiology, 2021
Periodontal disease is a chronic infectious disease associated with a variety of bacteria, which can cause damage to the periodontal support structure and affect a variety of systemic system diseases such as cancer, cardiovascular disease, diabetes ...
Zhiying Zhang, Dongjuan Liu, Sai Liu, Shuwei Zhang, Yaping Pan   +4 more
semanticscholar   +1 more source

Role of Porphyromonas gingivalis in oral and orodigestive squamous cell carcinoma.

Periodontology, 2022
Oral and esophageal squamous cell carcinomas harbor a diverse microbiome that differs compositionally from precancerous and healthy tissues. Though causality is yet to be definitively established, emerging trends implicate periodontal pathogens such as ...
R. Lamont, Z. R. Fitzsimonds, Huizhi Wang, Shegan Gao   +3 more
semanticscholar   +1 more source

Cysteine Proteases of Porphyromonas Gingivalis [PDF]

Critical Reviews in Oral Biology & Medicine, 2001
The cysteine proteases of Porphyromonas gingivalis are extracellular products of an important etiological agent in periodontal diseases. Many of the in vitro actions of these enzymes are consistent with the observed deregulated inflammatory and immune features of the disease. They are significant targets of the immune responses of affected individuals
M A, Curtis, J, Aduse-Opoku, M, Rangarajan   +2 more
openaire   +2 more sources

High Levels of Leptin and Adipsin Are Associated with Clinical Activity in Early Rheumatoid Arthritis Patients with Overweight and Periodontal Infection

Diagnostics, 2023
Adipokines are associated with the pathogenesis of rheumatoid arthritis (RA) and are potential biomarkers of disease activity, periodontitis, and obesity.
Consuelo Romero-Sánchez, Juliette De Avila, Alejandro Ramos-Casallas, Lorena Chila-Moreno, Nathaly Andrea Delgadillo, Philippe Chalem-Choueka, César Pacheco-Tena, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano   +8 more
doaj   +1 more source

Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice

Frontiers in Cellular and Infection Microbiology, 2022
Background Porphyromonas gingivalis (Pg), the keystone pathogen in chronic periodontitis, is reported to initiate Alzheimer’s disease pathologies in preclinical studies.
Ting Gong, Qi Chen, Hongchen Mao, Yao V. Zhang, Huan Ren, Mengmeng Xu, H. Chen, Deqin Yang   +7 more
semanticscholar   +1 more source

Treatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388. [PDF]

, 2020
COR388, a small-molecule lysine-gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease.
Arastu-Kapur, Shirin, Araujo, Joseph, De Lannoy, Ines AM, Dominy, Stephen S, Ermini, Florian, Haditsch, Ursula, Holsinger, Leslie J, Lynch, Casey, Nguyen, Mai, Raha, Debasish, Ryder, Mark I   +10 more
core   +1 more source

Antibacterial effect of a gingival patch containing nano-emulsion of red dragon fruit peel extract on Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum assessed in vitro

Journal of Oral Biology and Craniofacial Research, 2023
Background: The most common bacteria causing periodontitis were Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans.
Indeswati Diyatri, Wisnu Setyari Juliastuti, Rini Devijanti Ridwan, Ghinalya Chalbi Ananda, Fuad Adhi Waskita, Nita Vania Juliana, Shafa Putri Khansa, Reinaya Tifa Pratiwi, Cindy Ramadhan Putri   +8 more
doaj   +1 more source