Results 191 to 200 of about 10,981,272 (272)

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Prediction of Ceiling Temperature in Tunnel Fires Under Canyon‐Wind Conditions Using Ensemble Learning

Safety Science and Technology, EarlyView.
A LightGBM‐based ensemble learning framework with SHAP interpretability analysis was developed for predicting ceiling temperature in canyon‐wind tunnel fires. The model demonstrated robust generalization (R2 = 0.7476) under unseen extreme conditions, with fire‐source location identified as the primary factor driving temperature evolution.
Qinqin Zhu, Xinyu Wang, Ao Jiao, Feifei Liu, Junyi Li, Chuangang Fan   +5 more
wiley   +1 more source

The winter 2023/2024 floods in the UK: a hydrological appraisal

Weather, EarlyView.
From October 2023 to March 2024, the UK saw a succession of named storms and low‐pressure weather systems, leading to widespread exceptional river flows throughout. Peak flow records were broken in several catchments, but this event was most notable for its duration and spatial footprint, which resulted in major impacts.
Eugene Magee, Rachael Armitage, Wilson Chan, Gayatri Suman, Amit Kumar, Lucy J. Barker, Stephen Turner, Jamie Hannaford, Catherine Sefton   +8 more
wiley   +1 more source

Hepatosplenic Volumes and Portal Pressure Gradient Identify One-year Further Decompensation Risk Post-transjugular Intrahepatic Portosystemic Shunt.

J Clin Transl Hepatol
Chen X, Lin Y, Jia K, Lv R, Tian J, Li F, Li J, Zhang Y, Wang N, Gao Z, Yin W, Wang F, Zhu P, Yang C, Wang J, Wang T, Yan J, Liu Y, Ye Q, Xiang H.   +19 more
europepmc   +1 more source

The 2026 cold wave brought northern Fennoscandia its coldest 2‐week period since 1987

Weather, EarlyView.
During late December 2025 and January 2026, a severe and long‐lasting cold wave affected northern Fennoscandia. In this article, we aim to quantify the extremity of the 2026 cold wave and evaluate the atmospheric conditions that led to the persistent cold anomalies.
Daan van den Broek, Mika Rantanen
wiley   +1 more source

Is the rent too high? Land ownership and monopoly power

Real Estate Economics, EarlyView.
Abstract Pricing power in real estate markets can reduce housing supply and redevelopment relative to the social optimum. We show how pricing power interacts with popular redevelopment subsidies and zoning regulations. Using building‐level rental income data from NYC, we find that increased concentration is correlated with increased rents.
C. Luke Watson, Oren Ziv
wiley   +1 more source

Rebuilding the Ladder? Contemporary Contests Over Industrial Policy

Global Policy, EarlyView.
ABSTRACT Does the greater embrace of industrial policy globally signal the emergence of a New Washington Consensus? We show that the multiplication of industrial policies, while consequential, signals neither normalisation nor consensus. Rather, industrial policy is increasingly the object of contestation over norms and practices of state ...
Ilias Alami, Jack Taggart, Tom Chodor
wiley   +1 more source

Opium Cultivation Imperilling Endangered Species in Northern Laos

Animal Conservation, EarlyView.
To avoid government eradication efforts, farmers in northeastern Laos shifted opium cultivation deep into a national park, causing a > 1000% increase in protected forest cleared for the crop between 2018 and 2022. This displacement directly threatened endangered species like white‐cheeked gibbons, elephants, and dholes by causing a rise in hunting ...
Jay White, Khamphui Invixay, Akchousanh Rasphone, Vincent Nijman   +3 more
wiley   +1 more source

Conservation Priority Areas for Endemic and Threatened Bird Species in the Brazilian Amazon Under Climate Change: A Multifaceted Approach

Animal Conservation, EarlyView.
Climate change is projected to substantially erode taxonomic, phylogenetic, and functional diversity of endemic and threatened birds in the Brazilian Amazon by 2100. Integrating these dimensions with climate refugia revealed priority conservation areas, particularly in the eastern Amazon, highlighting where conservation efforts can best safeguard ...
Kauê Felippe de Moraes, Marcela Guimarães Moreira Lima, Gabriela Ribeiro Gonçalves, Dimas Augusto Molina Marin, Sara Miranda Almeida, Marcos Pérsio Dantas Santos   +5 more
wiley   +1 more source