Results 41 to 50 of about 4,504 (155)

Real World Posaconazole Pharmacokinetic Data in Paediatric Stem Cell Transplant Recipients

Children
Background: Invasive fungal disease is a significant cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. Posaconazole, a broad-spectrum triazole, is widely used as prophylaxis.
Csaba Kassa, Katalin Csordás, Lídia Hau, Orsolya Horváth, Krisztián Kállay, Gabriella Kertész, Márton Kiss, János Sinkó, Ágnes Wolfort, Gergely Kriván   +9 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Posaconazole in the management of refractory invasive fungal infections [PDF]

, 2008
Stefan Langner, Philipp B Staber, Peter NeumeisterDivision of Hematology, Department of Internal Medicine, Medical University of Graz, AustriaAbstract: The rising incidence of invasive fungal infections due to the expanding population of ...
Stefan Langner, Peter Neumeister, Philipp B Staber   +2 more
core  

Formation and Characterisation of Posaconazole Hydrate Form

, 2022
Posaconazole is an API added as Form I for the production of oral suspensions, but it is found as Form-S in the final formulation. In this study, it was found that this polymorphic conversion, which may affect the bioavailability, is due to an ...
Michail Lykouras, Lykouras, Michail, Orkoula, Malvina, Kontoyannis, Christos, Malvina Orkoula, Christos Kontoyannis   +5 more
core   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Management of posaconazole-induced pseudohyperaldosteronism

, 2020
Posaconazole-induced pseudohyperaldosteronism (PIPH) has been associated with elevated posaconazole serum concentrations. Clinicians are faced with the difficult task of managing patients with PIPH while maintaining the efficacy of antifungal therapy ...
Thompson, George R., Gintjee, Thomas J., Davis, Matthew R., Odermatt, Alex, Nguyen, Minh-Vu H., Young, Brian Y.   +5 more
core   +1 more source

Pronounced Reductions in Plasma Citrulline Indicate Severe Intestinal Mucosal Barrier Injury During Induction Therapy for Pediatric Acute Myeloid Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Pediatric acute myeloid leukemia (AML) chemotherapy regimens are frequently burdened by fever episodes, systemic inflammation and bloodstream infections (BSI). Mucosal barrier injury may contribute to these complications, but its role in childhood AML remains uninvestigated.
Carla Warley Kjær, Maria Ebbesen Sørum, Silvia De Pietri, Claus Moser, Malene Johanne Petersen, Marianne Hoffmann, Henrik Hasle, Sarah Weischendorff, Klaus Müller   +8 more
wiley   +1 more source

Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta, Tong Wang, Susmita, Ditte Marie L. Saunte, Roderick Hay, Vincent Piguet   +5 more
wiley   +1 more source

Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis

, 2018
Javier Martínez-Casanova,1 Nuria Carballo,1 Sonia Luque,1 Luisa Sorli,2 Santiago Grau1 1Pharmacy Department, Hospital del Mar, Barcelona, Spain; 2Infectious Diseases Department, Hospital del Mar, Barcelona, Spain Abstract: Azole antifungals have ...
Santiago Grau, Luque S, Carballo Martínez, Núria, Sorli Redó, M. Luisa, Luisa Sorli, Javier Martínez-Casanova, Grau S, Carballo N, Martínez-Casanova J, Sorli L, Luque Pardos, Sònia, Sonia Luque, Martínez-Casanova, Javier, Grau Cerrato, Santiago, Nuria Carballo   +14 more
core   +1 more source

Posaconazole inhibits multiple steps of the alphavirus replication cycle [PDF]

, 2021
Repurposing drugs is a promising strategy to identify therapeutic interventions against novel and re-emerging viruses. Posaconazole is an antifungal drug used to treat invasive aspergillosis and candidiasis.
Overheul, Gijs J, Teppor, Mona, Taskopru, Ezgi, van Rij, Ronald P., Meutiawati, Febrina, Merits, Andres, de Keyzer, Carolien, Overheul, Gijs J., van Woudenbergh, Esther, Bouma, Ellen, Delang, Leen, Smit, Jolanda M., Jacobs, Sofie, van Rij, Ronald P, Varghese, Finny S., Varghese, Finny S, Smit, Jolanda M   +16 more
core   +2 more sources