Results 131 to 140 of about 3,179,942 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Lateral Position Measurement Based on Vehicles' Longitudinal Displacement. [PDF]
Sensors (Basel), 2020 Mohsen I, Ditchi T, Holé S, Géron E.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Embodied Measurements of Ideological Positioning.
, 2019 Prior studies have shown tests for scales used to describe an individuals ideological position are not replicable. Weexamined ideological positioning of individuals through two mouse tracking tasks. First, participants were asked to selectfrom six ideologies, mixed with distractors, they believed described them.
Batzloff, Brandon, Spivey, Michael
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Enhancing Positional Accuracy of Mechanically Modified Industrial Robots Using Laser Trackers
RoboticsHighly accurate positioning of industrial robots is crucial to performing industrial operations with high quality. This paper presents a mechanical modification to an industrial robot aiming at enhancing the system actuation resolution, thereby enhancing
Mojtaba A. Khanesar +5 more
doaj +1 more source
Accurate positioning of long, flexible ARM's (Articulated Robotic Manipulator) [PDF]
An articulated robotic manipulator (ARM) system is being designed for space applications. Work being done on a concept utilizing an infinitely stiff laser beam for position reference is summarized.
Malachowski, Michael J.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source