Results 191 to 200 of about 1,182,692 (300)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Human-animal relationships in older persons: from pet companionship to animal-assisted interventions. A position statement. [PDF]

Aging Clin Exp Res
Ungar A, Ambrosino I, Rivasi G, Ceolin L, Bellelli G, Bisconti E, Catalani MC, Cherubini A, Colombo L, Contalbrigo L, Cotroneo AM, Mariti C, Mechelli L, Melosi M, Morandi A, Mutinelli F, Mussi C.   +16 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The International Match Calendar in Men's Professional Football: An Expert Position Statement. [PDF]

Scand J Med Sci Sports
Den Hollander S, Burgess D, Kerkhoffs G, Gouttebarge V.   +3 more
europepmc   +1 more source

Position statement

In recent years, skin reactions secondary to the use of medical devices (MD), such as allergic contact dermatitis have increasingly been observed (e.g. to continuous blood sugar monitoring systems, insulin pumps, wound dressings, medical gloves, etc.): this is regarded as a developing epidemic.
Herman, Anne||, Uter, Wolfgang||, Rustemeyer, Thomas||, Matura, Mihály, Aalto-Korte, Kristiina, Duus Johansen, Jeanne, Gonçalo, Margarida||, White, Ian R., Balato, Anna||, Giménez-Arnau, Ana M||, Brockow, Knut||, Mortz, Charlotte G||, Mahler, Vera||, Goossens, An   +13 more
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Transcatheter Aortic Valve Implantation: British Cardiovascular Intervention Society Position Statement. [PDF]

Interv Cardiol
Hildick-Smith D, Blackman DJ, Byrne J, Redwood S, Appleby C, Khan F, Kharbanda R, Dorman SH, Doshi SN, Anderson RA, Watkins S, Mullen MJ, MacCarthy PA, Malkin CJ, Mikhail GW, Khogali SS, Muir DF, Manoharan G, Newton JD, Banning AP.   +19 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Taiwan Association of Thoracic and Cardiovascular Surgery (TATCS) Position Statement: Surgeon's Role in the Present Era of Isolated Severe Aortic Stenosis Patient Management. [PDF]

Acta Cardiol Sin
Chang CY, Lee YT, Lin CY, Chang JC, Chen IC, Chen SW, Chen YC, Cheng BC, Chi NH, Hsieh CC, Hsu CP, Kang PL, Ke HY, Li PC, Lin CH, Roan JN, Shen TC, Tsai YT, Wang CH, Wu NC, Shih CC.   +20 more
europepmc   +1 more source