Results 181 to 190 of about 1,182,692 (300)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Community-Acquired Pneumonia and Acid-Suppressive Drugs: Position Statement

Canadian Journal of Gastroenterology, 2006
CAG Clinical Affairs Committee
doaj   +1 more source

UK National Screening Committee position statement on surrogate outcomes in cancer screening trials.

BMJ
Batson S, Hackshaw A, Mackie A, Richards M, Given-Wilson R, Atakpa E, Njagi EN, Shinkins B, Callender T, Hyde C, Visintin C, Thompson D, Cozens E, Evans DG, Hemming K, Payne K, Halligan S, Taylor-Phillips S.   +17 more
europepmc   +1 more source

Patient Education in Chronic Kidney Disease: A Position Statement of the Polish Society of Nephrology. [PDF]

Int J Nephrol Renovasc Dis
Lichodziejewska-Niemierko M, Mosakowska M, Adamczak M, Naumnik B.   +3 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

FIGO position statement on surrogacy: Ethical considerations. [PDF]

Int J Gynaecol Obstet
Zadykowicz R, Watson K, Antsaklis A, FIGO Committee on Ethical Aspects of Human Reproduction and Women's Health.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Correction: The support of early-career researchers in health professions education—an expert position statement

Frontiers in Medicine
Doreen Herinek, Franziska Matthes, Mohamed Al-Eraky, Elizabeth Anderson, Julie Browne, Maria Cassar, Ingrid Darmann-Finck, Götz Fabry, Marion Huber, Fiona Kent, Mirjam Körner, Sylvia Langlois, Kristina Mikkonen, Elise Paradis, Lisa Quinn, Ara Tekian, Daniëlle Verstegen, Robyn Woodward-Kron, Michael Ewers   +18 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Position Statement on Cardiometabolic Health Across the Woman's Life Course - 2025. [PDF]

Rev Bras Ginecol Obstet
de Oliveira GMM, de Almeida MCC, Valério CM, Giuffrida F, Espíndola LN, Izar MCO, Marques-Santos C, Freire CMV, Albuquerque CJDM, Chagas ACP, Précoma DB, Mesquita ET, Saraiva JFK, Costa MENC, Lemke VMG, de Lucena AJG, Brandão AA, Fagundes AAP, Macedo AVS, Polanczyk CA, Leitão CB, Silveira DS, Coutinho EDR, Nahas EAP, Alexandre ERG, Campana EMG, Bragança EOV, Colombo FMC, Barbosa ICQ, Rivera IR, Kulak J, Salles JEN, de Sá JR, Soares JM, Dourado LA, Moura LZ, Magalhães LBNC, Pompei LM, Passaglia LG, Assad MHV, Rodrigues MAH, Rivera MAM, Lopes MAAAM, Paiva MSMO, de Castro ML, Campos MDSB, de Souza OF, de Medeiros OO, Freitas RAP, de Carvalho RCM, da Silva SCTF, Rodrigues TCV, Avila WS, da Silva WS, Nazima WI, da Costa-Paiva LHS, Wender MCO.   +56 more
europepmc   +1 more source