Results 221 to 230 of about 7,373,496 (288)

A Case Report on Biot's Breathing: An Early Sign of Brainstem Dysfunction in Neonatal Bacterial Meningitis. [PDF]

Cureus
Badr El Din S, Lecart C, Bachy A.
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Persistent Hypoxia After Tricuspid Valve Replacement. [PDF]

JACC Case Rep
Nguyen J, Merino T, Kandula V, Castillo Kontak L, Mercado Garcia R, Caldera A, Shankar A, Gonzalez R, Neravetla S, Condado JF.   +9 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Predictor of Mortality in Obstructive Sleep Apnea: Results of Explainable Deep Learning-Based Survival Analysis from a 15-Year Follow-Up.

Respiration
Pagano G, Castellana G, D Apos Addio G, Palazzo L, Aliani M, Guido P, Berloco F, Marvulli PM, Suglia V, Colucci S, Lacedonia D, Bevilacqua V, Carone M.   +12 more
europepmc   +1 more source

Impact of noradrenaline, adrenergic receptors, and radical formation on cardiac mitochondria in resuscitated swine. [PDF]

Intensive Care Med Exp
Abele N, Merz T, Zink F, Hoffmann A, Gröger M, Kress S, Kranz S, Seifritz A, Passarelli V, Münz F, Feth M, Scheer M, Sharon O, Hogg M, Wolfschmitt EM, Wachter U, Schulz T, Calzia E, Fage N, Waller C, Asfar P, Radermacher P, Kapapa T.   +22 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Quantification of ventilatory control in sleep apnea: from physiological insight to computable loop gain. [PDF]

Sleep
Nassi T, Oppersma E, Donker DW, Westover MB, Thomas RJ.   +4 more
europepmc   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Seated Sedation-Analgesia With Preserved Spontaneous Ventilation to Facilitate Intubation After Transition to the Supine Position: A Case Report. [PDF]

Cureus
Tagawa R, Shakuo T, Yamazaki Y, Masunaga N, Shida K.   +4 more
europepmc   +1 more source