Results 231 to 240 of about 31,985 (308)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Glutathione-Based Photoaffinity Probe Identifies Caffeine as a Positive Allosteric Modulator of the Calcium-Sensing Receptor. [PDF]

ACS Chem Biol
Matarage Don NNJ, Padmavathi R, Khasro TD, Zaman MRU, Ji HF, Ram JL, Ahn YH.   +6 more
europepmc   +1 more source

Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth

The Journal of Physiology, EarlyView.
Abstract figure legend Increases in testosterone are associated with developmental changes in motor‐related neural oscillations in youth. Abstract Motor control is critical to daily functioning and undergoes significant refinement throughout youth. Although the effects of age on the underlying brain circuitry have been well characterized, fewer studies
Jackson Derby, Thomas W. Ward, Nathan M. Petro, Jake J. Son, Grace C. Ende, Danielle L. Rice, Anna T. Coutant, Erica L. Steiner, Vince D. Calhoun, Yu‐Ping Wang, Julia M. Stephen, Elizabeth Heinrichs‐Graham, Tony W. Wilson   +12 more
wiley   +1 more source

Discovery of VU6008677: A Structurally Distinct Tricyclic M₄ Positive Allosteric Modulator with Improved CYP450 Profile. [PDF]

ACS Med Chem Lett
Capstick RA, Bollinger SR, Engers JL, Long MF, Chang S, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ.   +13 more
europepmc   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Opioid Analgesic as a Positive Allosteric Modulator of Acid-Sensing Ion Channels. [PDF]

Int J Mol Sci
Osmakov DI, Onoprienko LV, Kalinovskii AP, Koshelev SG, Stepanenko VN, Andreev YA, Kozlov SA.   +6 more
europepmc   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Determination of the Cannabinoid CB1 Receptor's Positive Allosteric Modulator Binding Site through Mutagenesis Studies. [PDF]

Pharmaceuticals (Basel)
Green HM, Fellner DMJ, Finlay DB, Furkert DP, Glass M.   +4 more
europepmc   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source