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ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics. [PDF]

Eur J Clin Pharmacol
Nilsson B, Bylund J, Halldin MM, Rother M, Rein-Hedin E, Önnestam K, Segerdahl M.   +6 more
europepmc   +1 more source

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Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial

Lancet, The, 2022
BACKGROUND Emraclidine is a novel, brain-penetrant, highly selective M4 receptor positive allosteric modulator in development for the treatment of schizophrenia.
J. Krystal, J. Kane, C. Correll, D. Walling, M. Leoni, S. Duvvuri, Shrinal Patel, I. Chang, P. Iredale, Lillian C. Frohlich, Stacey Versavel, P. Perry, R. Sanchez, J. Renger   +13 more
exaly   +2 more sources

Identification of dual role of piperazine-linked phenyl cyclopropyl methanone as positive allosteric modulator of 5-HT2C and negative allosteric modulator of 5-HT2B receptors

European Journal of Medicinal Chemistry, 2019
Allosteric modulators of G-protein-coupled receptors have lately gained significant traction in drug discovery. Recent studies have shown that allosteric modulation of serotonin 2C receptor (5-HT2C) as a viable strategy for the treatment of various ...
Kartikey Singh, Chandan Sona, Maninder Singh   +2 more
exaly   +2 more sources