Results 101 to 110 of about 459,027 (261)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dimension of the set of positive solutions to nonlinear equations and applications

Electronic Journal of Differential Equations, 2016
We study the covering dimension of the set of (positive) solutions to various classes of nonlinear equations involving condensing and A-proper maps. It is based on the nontriviality of the fixed point index of a certain condensing map or on oddness ...
Petronije S. Milojevic
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Stress transfer using the Okada dislocation model: A case study of the Gorkha Earthquake

Bibechana
We study the static Coulomb stress change (ΔCFS) produced by  2015 Gorkha earthquake using a rectangular fault model and the Okada (1992) elastic dislocation solution in a homogeneous, isotropic half-space.
Eak Raj Paudel, Ram Krishna Tiwari, Uday Bahadur Thapa Kshetri, Rudra Poudel, Harihar Paudyal   +4 more
doaj   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Measurement of the Full Shape of the Thermal Sunyaev–Zel’dovich Power Spectrum from the South Pole Telescope and Herschel–SPIRE Observations

The Astrophysical Journal Letters
We present a measurement of the full shape of the power spectrum of the thermal Sunyaev–Zel’dovich (tSZ) effect down to arcminute scales using cosmic microwave background (CMB) data from the South Pole Telescope (SPT) over a roughly 100 deg ^2 field. The
S. Raghunathan, P. A. R. Ade, D. Anbajagane, A. J. Anderson, B. Ansarinejad, M. Archipley, J. E. Austermann, L. Balkenhol, D. R. Barron, P. S. Barry, J. A. Beall, K. Benabed, A. N. Bender, B. A. Benson, F. Bianchini, L. E. Bleem, J. Bock, S. Bocquet, F. R. Bouchet, L. Bryant, E. Camphuis, M. G. Campitiello, J. E. Carlstrom, J. Carron, C. L. Chang, P. Chaubal, H. C. Chiang, P. M. Chichura, A. Chokshi, T.-L. Chou, R. Citron, A. Coerver, C. Corbett Moran, T. M. Crawford, A. T. Crites, C. Daley, T. de Haan, K. R. Dibert, M. A. Dobbs, M. Doohan, A. Doussot, D. Dutcher, W. Everett, C. Feng, K. R. Ferguson, N. C. Ferree, K. Fichman, A. Foster, S. Galli, J. Gallicchio, A. E. Gambrel, A. K. Gao, R. W. Gardner, F. Ge, E. M. George, N. Goeckner-Wald, R. Gualtieri, F. Guidi, S. Guns, N. Gupta, N. W. Halverson, E. Hivon, A. Y. Q. Ho, G. P. Holder, W. L. Holzapfel, J. C. Hood, J. D. Hrubes, A. Hryciuk, N. Huang, J. Hubmayr, K. D. Irwin, T. Jhaveri, F. Kéruzoré, A. R. Khalife, L. Knox, M. Korman, K. Kornoelje, C.-L. Kuo, A. T. Lee, K. Levy, Y. Li, D. Li, A. E. Lowitz, A. Lowitz, C. Lu, G. P. Lynch, T. J. Maccarone, A. S. Maniyar, E. S. Martsen, J. J. McMahon, F. Menanteau, M. Millea, J. Montgomery, Y. Nakato, T. Natoli, J. P. Nibarger, G. I. Noble, V. Novosad, Y. Omori, A. Ouellette, S. Padin, Z. Pan, P. Paschos, S. Patil, K. A. Phadke, A. W. Pollak, K. Prabhu, C. Pryke, W. Quan, M. Rahimi, A. Rahlin, C. L. Reichardt, M. Rouble, J. E. Ruhl, B. R. Saliwanchik, K. K. Schaffer, E. Schiappucci, C. Sievers, A. C. Silva Oliveira, A. Simpson, G. Smecher, J. A. Sobrin, A. A. Stark, J. Stephen, C. Tandoi, B. Thorne, C. Trendafilova, C. Tucker, C. Umilta, T. Veach, J. D. Vieira, A. G. Vieregg, M. P. Viero, A. Vitrier, Y. Wan, G. Wang, N. Whitehorn, W. L. K. Wu, V. Yefremenko, M. R. Young, J. A. Zebrowski, M. Zemcov, the SPTpol and SPT-3G Collaboration   +142 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source