Results 61 to 70 of about 585,417 (307)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

General estimates for the linear positive operators which preserve linear functions

open access: yesJournal of Numerical Analysis and Approximation Theory, 1989
Not available.
Radu Păltănea
doaj   +2 more sources

Convergence Theorems for Derivatives of a New Baskakov -Type Operators

open access: yesWasit Journal for Pure Sciences
The motive of this paper is to introduce and investigate the derivatives of some Baskakov operators. Firstly, we treated with the convergence theorems on some certain type of Baskakov operators and then we found the derivative of these operators.
Haneen Jaafar, haneen jaafar
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Cohomology of classes of symbols and classi cation of traces on corresponding classes of operators with non positive order

open access: yes, 2010
This thesis is devoted to the classification issue of traces on classical pseudo-differential operators with fixed non positive order on closed manifolds of dimension $n>1$.
Neira Jiménez, C.
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Approximation by Certain Linear Positive Operators of Two Variables

open access: yesAbstract and Applied Analysis, 2014
We introduce positive linear operators which are combined with the Chlodowsky and Szász type operators and study some approximation properties of these operators in the space of continuous functions of two variables on a compact set. The convergence rate
Afşin Kürşat Gazanfer   +1 more
doaj   +1 more source

Common eigenvectors for commutative positive linear operators [PDF]

open access: yesProceedings of the American Mathematical Society, 1970
The purpose of this note is to point out an extension of the Markov-Kakutani fixed-point theorem to a result on the existence of a common eigenvector in a cone with a compact base when acted upon by a commutative family of operators. As an application, an extension is given of a result of Kreĭn and Rutman on characteristic functionals.
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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