Results 91 to 100 of about 327,787 (287)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Impact of parenting style disparities on mental health of medical college students: an analysis of mediating effects of positive psychological qualities

open access: yesFrontiers in Public Health
BackgroundResearch has shown that parenting style disparities have a significant impact on the mental health of college students. However, the underlying reasons behind this phenomenon have not been sufficiently explored.
Li Yang   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Intergenerational Parenting Styles and Children’s Problem Behaviors: The Mediating Role of the Grandparent–Parent Relationship

open access: yesBehavioral Sciences
In China, grandparents play a significant role in childrearing. This study aims to identify latent profiles of intergenerational parenting styles and explore their impact on grandchildren’s behavioral outcomes. A total of 1432 Chinese children (Mage = 12.
Furong Lu   +4 more
doaj   +1 more source

Positive parenting project

open access: yes, 2021
It is increasingly urgent to address issue around parenting. The family remains a fundamental loop in the wellbeing of society. I am a strong believer that healthy communities are founded on happy families, ‘happiness’ in the widest sense of the word.
Azzopardi, Andrew   +1 more
openaire   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Lien entre les pratiques parentales négatives et les problèmes de comportement extériorisés des jeunes enfants à leur entrée à la maternelle : effet modérateur des pratiques positives de l’autre parent

open access: yesEnfances, Familles, Générations, 2017
Research Framework: Studying the impact of both parents’ parenting practices suggests that, just as the mother’s, the father’s parenting practices make a positive contribution to the child’s social adjustment.
Camille Caron   +3 more
doaj  

Positive about parents [PDF]

open access: yes, 2009
Paper presented to the Scottish Institute for Residential Child Care Annual Conference, 2009: 'Seeing the whole picture: working in partnership to enhance the lives of children looked after away from home'
Pilkington, Kevin, Burns, Claire
openaire  

The importance of early parenting for later child outcomes: A study with Spanish families with children with disabilities [PDF]

open access: yes, 2018
Children with different disability conditions have varied developmental trajectories, which perhaps influences parent-child interaction. For these and all infants, an optimal home environment that includes good parenting and positive parent-child ...
Bersabe-Moran, Rosa Maria   +6 more
core  

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