Results 91 to 100 of about 5,058,316 (286)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Lien entre les pratiques parentales négatives et les problèmes de comportement extériorisés des jeunes enfants à leur entrée à la maternelle : effet modérateur des pratiques positives de l’autre parent

Enfances, Familles, Générations, 2017
Research Framework: Studying the impact of both parents’ parenting practices suggests that, just as the mother’s, the father’s parenting practices make a positive contribution to the child’s social adjustment.
Camille Caron, Thérèse Besnard, Pierrette Verlaan, France Capuano   +3 more
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Behavioral interventions for children and adolescents with attention deficit hyperactivity disorder: a meta-analysis of randomized controlled trials across multiple outcome domains [PDF]

, 2014
OBJECTIVE: Behavioral interventions are recommended as attention-deficit/hyperactivity disorder (ADHD) treatments. However, a recent meta-analysis found no effects on core ADHD symptoms when raters were probably blind to treatment allocation. The present
Cortese, Samuele, Ferrin, M, Sonuga-Barke, E.J.S., Daley, David, Ferrin, M., Sonuga-Barke, E.J., Cortese, S, Ferrin, Maite, Sonuga-Barke, Edmund J. S., European Adhd Guidelines Group,, Barke, Edmund, Daley, D, Doepfner, Manfred, Sonuga-Barke, Edmund J.S., Doepfner, M., Doepfner, M, Danckaerts, M., Sonuga-barke, Edmund, van der Oord, S, Oord, S. van der, Sonuga-Barke, Edmund J S, Buitelaar, J.K., Van der Oord, Saskia, Danckaerts, M, van der Oord, S., Cortese, S., Cortese, Sam, Daley, D., Sonuga-Barke, EJS, Danckaerts, Marina, et al.   +30 more
core   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The impact of parenting stress on problem behavior in girls with precocious puberty: Exploring the mediating role of family expressiveness

Acta Psychologica
Objective: To explore the mediating role of family expressiveness between parenting stress and problem behavior in girls with precocious puberty (PP), and to provide new ideas to improve the psycho-behavioral problems in this population.
Xianjie Ping, Hui Zhou, Yanan Liu, Ning Li   +3 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

A Parenting Programme for Muslims

, 2018
Universal parenting intervention courses often fail to recruit and retain Muslim families. The practice of targeting specific populations in parenting programs is not well established.
Thomson, Kathryn, Butterworth, Ruth, Hussein, Hanan, Roche-Nagi, Kathleen   +3 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source