Results 41 to 50 of about 84,319 (298)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Relationship between parenting style and internet addiction: Interpersonal relationship problem as a mediator and gender as a moderator

Heliyon
Purpose: This study assessed the moderating effect of gender on the indirect effects of positive and negative parenting styles on Internet addiction through interpersonal relationship problem.
Yaning Guo, HongYu Chen, Xuqun You, Xufeng Liu, Xiqing Sun, Yinchuan Jin   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Parenting practices and oral health behaviors of children in rural Egypt: gender differences in a household survey

BMC Oral Health, 2022
Background Parenting practices influence children’s health and development. The current study aimed at assessing gender differences in children’s perception of the parenting practices of both parents, and in the association between children’s oral health
Maha El Tantawi, Nourhan M. Aly, Sara Atteya, Enas Abdellatif, Randa Yassin   +4 more
doaj   +1 more source

Positive parenting, not physical punishment [PDF]

Canadian Medical Association Journal, 2012
See related analysis article by Durrant and Ensom on page [1373][1] and at [www.cmaj.ca/lookup/doi/10.1503/cmaj.101314][2] Is spanking wrong? Clearly, hitting anyone in anger or when losing an argument is bad behaviour.
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Parenting in the early years: effectiveness of parenting support programs for Indigenous families [PDF]

, 2012
This resource sheet examines programs for Australian Indigenous families that effectively support parenting in the early years. This is not a systematic review of all programs; instead, it presents briefly on the evidence for parenting programs generally
Robyn Mildon, Melinda Polimeni
core  

Behavioral interventions for children and adolescents with attention deficit hyperactivity disorder: a meta-analysis of randomized controlled trials across multiple outcome domains [PDF]

, 2014
OBJECTIVE: Behavioral interventions are recommended as attention-deficit/hyperactivity disorder (ADHD) treatments. However, a recent meta-analysis found no effects on core ADHD symptoms when raters were probably blind to treatment allocation. The present
Cortese, Samuele, Ferrin, M, Sonuga-Barke, E.J.S., Daley, David, Ferrin, M., Sonuga-Barke, E.J., Cortese, S, Ferrin, Maite, Sonuga-Barke, Edmund J. S., European Adhd Guidelines Group,, Barke, Edmund, Daley, D, Doepfner, Manfred, Sonuga-Barke, Edmund J.S., Doepfner, M., Doepfner, M, Danckaerts, M., Sonuga-barke, Edmund, van der Oord, S, Oord, S. van der, Sonuga-Barke, Edmund J S, Buitelaar, J.K., Van der Oord, Saskia, Danckaerts, M, van der Oord, S., Cortese, S., Cortese, Sam, Daley, D., Sonuga-Barke, EJS, Danckaerts, Marina, et al.   +30 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Kampanye Pengasuhan Positif Melalui Buku Kecil (Booklet) Kepada Orangtua Dari Anak Prasekolah di Surabaya

Dinamisia, 2020
Many parents have difficulties in managing their child behavior. Therefore, positive parenting campaign through dissemination of parenting booklets was designed to help parents to understand and implement positive parenting strategies.
Agnes Maria Sumargi, Eli Prasetyo, Made Dharmawan Rama Adhyatma   +2 more
doaj   +1 more source