Results 51 to 60 of about 84,319 (298)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Understanding and supporting positive parenting during homelessness [PDF]
, 2016 This study aimed to develop and test the feasibility of a peer-led parenting intervention for parents living in London in temporary accommodation, seeking help with managing behavioural difficulties of a child (aged 2–11).
Bradley, C.
core
Examining the fabric of mindful parenting and mindfulness-based parenting interventions [PDF]
, 2023 Background: Research to date suggests Mindfulness-based Parenting interventions are beneficial for parents, children, and the parent-child relationship. Alongside examining efficacy, researchers have also begun to examine mechanisms of change. Aim: This
Griffiths, A.
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Parenting programmes in South Africa: investigating design and evaluation practices [PDF]
, 2012 Includes abstract.Includes bibliographical references.Parenting programmes have been shown to have wide-ranging benefits, including the prevention of behavioural and emotional problems in children as well as child maltreatment.
Wessels, Inge
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
HUBUNGAN POLA ASUH ORANGTUA DAN KEMANDIRIAN ANAK
Journal of EST (Educational Science And Technology), 2016 This study examines patterns of parenting and the child's self reliance. The research problem is whether there is a relationship between parenting parents and the child's self reliance?
Kustiah Sunarty
doaj +1 more source
Factors Influencing Parental Satisfaction of Mothers with Preschool Children [PDF]
Korean Journal of Women Health Nursing, 2016 PURPOSE: The purpose of the study was to identify degrees of parenting stress, parenting efficacy, parenting behavior and parental satisfaction, and to identify factors influencing parenting satisfaction of mothers who had preschool children.
Hye Min Jeong, Hye Young Kim
doaj +1 more source
Indian Journal of Psychiatric Nursing, 2021 Introduction: The parent plays a vital role in promoting and supporting the overall development of children from infancy to adulthood. Parenting practices are related to different outcomes in children's life.
Amina Ahmed, A Baruah, L B Siddeswara
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source