Results 91 to 100 of about 96,168 (247)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Positive periodic solution for higher-order p-Laplacian neutral singular Rayleigh equation with variable coefficient

Boundary Value Problems, 2017
In this paper, we consider the existence of a positive periodic solution for the following kind of high-order p-Laplacian neutral singular Rayleigh equation with variable coefficient: ( φ p ( x ( t ) − c ( t ) x ( t − σ ) ) ( n ) ) ( m ) + f ( t , x ...
Yun Xin, Shaowen Yao, Zhibo Cheng
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Positive periodic solutions for neutral functional differential systems

Proyecciones (Antofagasta), 2017
We study the existence of positive periodic solutions of a system of neutral differential equations. In the process we construct two map- pings in which one is a contraction and the other compact. A Krasnoselskii's fixed point theorem is then used in the analysis.
Yankson, Ernest, Assabil, Samuel E.
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Positive periodic solutions for third-order nonlinear differential equations

Electronic Journal of Differential Equations, 2011
For several classes of third-order constant coefficient linear differential equations we obtain existence and uniqueness of periodic solutions utilizing explicit Green's functions.
Jingli Ren, Stefan Siegmund, Yueli Chen
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Existence and multiplicity of positive periodic solutions for first-order singular systems with impulse effects

Electronic Journal of Differential Equations, 2013
In this article, we consider the existence and multiplicity of positive periodic solutions for a first-order singular system with impulse effects. The proof of our main result is based on Krasnoselskii's fixed point theorem in a cone.
Bian-Xia Yang
doaj  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Necessary and sufficient conditions for the existence of periodic solution to singular problems with impulses

Electronic Journal of Differential Equations, 2014
In this article we give a necessary sufficient conditions for the existence of periodic solutions to impulsive periodic solution for a singular differential equation. The proof is based on the variational method.
Juntao Sun, Jifeng Chu
doaj