Results 101 to 110 of about 4,136,009 (408)

Predictive Modeling: An Optimized and Dynamic Solution Framework for Systematic Value Investing [PDF]

open access: yesarXiv, 2017
This paper defines systematic value investing as an empirical optimization problem. Predictive modeling is introduced as a systematic value investing methodology with dynamic and optimization features. A predictive modeling process is demonstrated using financial metrics from Gray & Carlisle and Buffett & Clark.
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

A precise machine learning aided algorithm for land subsidence or upheave prediction from GNSS time series [PDF]

open access: yesarXiv, 2020
This paper is aimed at the problem of predicting the land subsidence or upheave in an area, using GNSS position time series. Since machine learning algorithms have presented themselves as strong prediction tools in different fields of science, we employ them to predict the next values of the GNSS position time series.
arxiv  

Transrectal Sonography in Prostate Cancer Detection – Our 25 Years Experience of Implementation [PDF]

open access: yes, 2010
Prostate cancer is a leading public health problem of male population in developed countries. Gold standard for prostate cancer diagnosis is true cut biopsy guided by transrectal ultrasound1–5. Aim of this study was to determine sensitivity, specificity,
Aldo Ivančić   +5 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

On the Utility of Prediction Sets in Human-AI Teams [PDF]

open access: yesarXiv, 2022
Research on human-AI teams usually provides experts with a single label, which ignores the uncertainty in a model's recommendation. Conformal prediction (CP) is a well established line of research that focuses on building a theoretically grounded, calibrated prediction set, which may contain multiple labels.
arxiv  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

Long Short-Term Memory to predict 3D Amino acids Positions in GPCR Molecular Dynamics [PDF]

open access: yesarXiv, 2022
G-Protein Coupled Receptors (GPCRs) are a big family of eukaryotic cell transmembrane proteins, responsible for numerous biological processes. From a practical viewpoint around 34\% of the drugs approved by the US Food and Drug Administration target these receptors.
arxiv  

Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions [PDF]

open access: yes, 2012
Background There are currently no reliable markers of acute domoic acid toxicosis (DAT) for California sea lions. We investigated whether patterns of serum peptides could diagnose acute DAT.
Almeida, Jonas S   +7 more
core   +3 more sources

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi   +3 more
wiley   +1 more source

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