Results 101 to 110 of about 11,536,029 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Positive predictive value of first-time rheumatoid arthritis diagnoses and their serological subtypes in the Danish National Patient Registry

, 2018
Asta Linauskas,1,2 Kim Overvad,3 Martin Berg Johansen,4 Kristian Stengaard-Pedersen,1,5 Annette de Thurah1,5 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Rheumatology, North Denmark Regional Hospital, Hjoerring,
Overvad K, Linauskas A, Johansen MB, Stengaard-Pedersen K, de Thurah A   +4 more
core  

Sensitivity, specificity, negative predictive value, and positive predictive value of S ser. Typhi IgM/IgG rapid test.

, 2014
TP, true positive; FN, false negative; FP, false positive; FN, false negative.Sensitivity, specificity, negative predictive value, and positive predictive value of S ser. Typhi IgM/IgG rapid test.
Narong Henpraserttae (655628), Wannee Limpitikul (580302), Kamolwish Laoprasopwattana (424106), Rachanee Saksawad (655629)   +3 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Positive predictive value of diagnosis coding for hemolytic anemias in the Danish National Patient Register

, 2016
Dennis Lund Hansen,1 Ulrik Malthe Overgaard,2 Lars Pedersen,3 Henrik Frederiksen1,3 1Department of Haematology, Odense University Hospital, Odense, 2Department of Haematology, Herlev Hospital, Herlev, 3Department of Clinical Epidemiology, Aarhus ...
Frederiksen H, Pedersen L, Hansen DL, Overgaard UM   +3 more
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Positive Predictive Value of the ICD-10 Diagnosis Code for Long-COVID

Clinical Epidemiology, 2022
Lærke Storgaard Duerlund,1 Shakil Shakar,2 Henrik Nielsen,1 Jacob Bodilsen1 1Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark; 2The Department of Medicine, Regionshospitalet Nordjylland Hjørring, Hjørring ...
Duerlund LS, Shakar S, Nielsen H, Bodilsen J   +3 more
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Interpretation of a diagnostic test in statistical terms

Current Medicine Research and Practice, 2012
In medical practice, various tests are used for confirmation or diagnosis of a disease. For clinical implications, these tests are compared with the definitive test which is the gold standard and their diagnostic utility is expressed by various ...
Vivek Choudhury, Anita Singh, Satish Saluja   +2 more
doaj  

Sensitivity, specificity, positive predictive value, and negative predictive value of self-reported BMI classifications.

Sensitivity, specificity, positive predictive value, and negative predictive value of self-reported BMI classifications.
Aseel Ehsanallah (18405180), Dalia Haroun (2512513)   +1 more
core   +1 more source