Results 41 to 50 of about 70,362 (262)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Non-existence of positive radial solution for semipositone weighted p-Laplacian problems
Electronic Journal of Differential Equations, 2015 We prove the non-existence of positive radial solution to a semipositone weighted $p$-Laplacian problem whenever the weight is sufficiently large. Our main tools are a Pohozaev type identity and a comparison principle.
Sigifredo Herron, Emer Lopera
doaj
Existence of positive radial solution for the elliptic system on an exterior domain
Boundary Value ProblemsThis article discusses the existence of positive radial solution for the elliptic system { − △ u = K ( | x | ) f ( | x | , u , v , | ∇ u | ) , x ∈ Ω , − △ v = K ( | x | ) g ( | x | , u , v , | ∇ v | ) , x ∈ Ω , α 1 u + β 1 ∂ u ∂ n | ∂ Ω = 0 , α 2 v + β 2
Dan Wang, Yongxiang Li, Shengbin Yang
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Localized radial solutions for a nonlinear p-Laplacian equation in $R^N$
Electronic Journal of Qualitative Theory of Differential Equations, 2008 We establish the existence of radial solutions to the p-Laplacian equation $ \Delta_p u + f(u)=0 $ in $\mathbb {R^N}$, where $f$ behaves like $|u|^{q-1}u$ when $u$ is large and $f(u) < 0$ for small positive $u$. We show that for each nonnegative integer
S. Pudipeddi
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Radial solutions for a nonlocal boundary value problem
Boundary Value Problems, 2006 We consider the boundary value problem for the nonlinear Poisson equation with a nonlocal term −Δu=f(u,∫Ug(u)), u|∂U=0. We prove the existence of a positive radial solution when f grows linearly in u, using Krasnoselskiiés fixed ...
Luís Sanchez +1 more
doaj +2 more sources
A system of equations involving the fractional p-Laplacian and doubly critical nonlinearities
Advanced Nonlinear Studies, 2023 This article deals with existence of solutions to the following fractional pp-Laplacian system of equations: (−Δp)su=∣u∣ps*−2u+γαps*∣u∣α−2u∣v∣βinΩ,(−Δp)sv=∣v∣ps*−2v+γβps*∣v∣β−2v∣u∣αinΩ,\left\{\begin{array}{l}{\left(-{\Delta }_{p})}^{s}u={| u| }^{{p}_{s}^{
Bhakta Mousomi +2 more
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FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Journal of Differential Equations, 2012 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wang, Biao, Zhang, Zheng-ce, Li, Yi
openaire +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source